Willis-Ekbom disease is not associated with poor cardiovascular health in adults

Journal of Negative Results in Biomedicine

Pablo R. Castillo²  Augustine S. Lee²  Oscar H. Del Brutto¹  Brynn K. Dredla³ 

[1] School of Medicine, Universidad Espíritu Santo, Guayaquil, Ecuador;Division of Pulmonary and Allergy Medicine, Mayo Clinic, 4500 San Pablo Rd, Jacksonville 32224, FL, USA;Department of Neurology, Mayo Clinic, Jacksonville, FL, USA

关键词: Sleep;    Restless legs syndrome;    Cardiovascular risk;   

Others  :  1231244
DOI  :  10.1186/s12952-015-0038-4

 received in 2015-05-22, accepted in 2015-11-03,  发布年份 2015

【 摘 要 】

Background

Willis-Ekbom disease (WED), also called restless legs syndrome (RLS), is a neurologic sensorimotor disease that may be associated with cardiovascular disease. Given high morbidity and mortality rates of cardiovascular disease worldwide, we assessed the relation between WED/RLS and cardiovascular health risks in a native South American population. We prospectively analyzed data from The Atahualpa Project of Ecuadorian adults aged 40 years and older. Physicians interviewed consented persons on the health behavior and health factors of the American Heart Association (AHA) for ideal cardiovascular health in adults and underwent fasting laboratory blood collection and blood pressure evaluation. Certified neurologists conducted face-to-face interviews using the International Restless Legs Syndrome Study Group (IRLSSG) field instrument. Persons testing positive for WED/RLS and age-and sex-matched controls underwent confirmatory physical examinations conducted by a neurologist and a sleep specialist to whom IRLSSG designation was blinded.

Findings

Of 665 persons, 94 (14 %) tested positive in IRLSSG; 40 (6 %) had a diagnosis of WED/RLS after neurologic examination and interview. Patients with WED/RLS were younger (53.5 vs 59.9 years, P = .001), without significant differences in sex ratios. Among AHA risk factors, only obesity was significantly more prevalent among patients with WED/RLS (42.5 % vs 23.5 %, P = .01). However, after adjustment for confounders, body mass index was not significantly associated with WED/RLS.

Conclusions

In adult Amerindians, although obesity and body mass index were associated with WED/RLS on univariate analyses, the association was not present after adjustment for confounders. No other significant associations were found between WED/RLS and AHA cardiovascular metrics.

【 授权许可】

   
2015 Dredla et al.

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