Immunological parameters in girls with Turner syndrome

Journal of Negative Results in Biomedicine

Malou Hultcrantz¹  Carl GM Magnusson³  Lisskulla Sylvén²  Annika E Stenberg¹ 

[1] Dept. of Otorhinolaryngology, Karolinska University Hospital, Stockholm, Sweden;Dept. of Woman and Child Health, Karolinska University Hospital, Stockholm, Sweden;Dept. Clin. Chemistry, Engelholm hospital, Engelholm, Sweden

关键词: otitis media;    hearing;    immunoglobulins;    lymphocytes;    Antibodies;   

Others  :  824232
DOI  :  10.1186/1477-5751-3-6

 received in 2002-10-23, accepted in 2004-11-25,  发布年份 2004

【 摘 要 】

Disturbances in the immune system has been described in Turner syndrome, with an association to low levels of IgG and IgM and decreased levels of T- and B-lymphocytes. Also different autoimmune diseases have been connected to Turner syndrome (45, X), thyroiditis being the most common.

Besides the typical features of Turner syndrome (short stature, failure to enter puberty spontaneously and infertility due to ovarian insufficiency) ear problems are common (recurrent otitis media and progressive sensorineural hearing disorder).

Levels of IgG, IgA, IgM, IgD and the four IgG subclasses as well as T- and B-lymphocyte subpopulations were investigated in 15 girls with Turners syndrome to examine whether an immunodeficiency may be the cause of their high incidence of otitis media. No major immunological deficiency was found that could explain the increased incidence of otitis media in the young Turner girls.

【 授权许可】

   
2004 Stenberg et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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