Journal of Cardiothoracic Surgery | |
A comparison of off-pump and on-pump coronary bypass surgery in patients with low EuroSCORE | |
Davit Saba1  Tolga Onder2  Gencehan Kumtepe3  Orcun Gurbuz3  Ilker Hasan Karal2  Abdulkadir Ercan3  | |
[1] Department of Cardiovascular Surgery, Uludag University, School of Medicine, Bursa, Turkey;Department of Cardiovascular Surgery, Samsun Hospital for Education and Research, Ilkadim 55090, Samsun, Turkey;Department of Cardiovascular Surgery, Balikesir University, School of Medicine, Balikesir 10010, Turkey | |
关键词: Off-pump; Low-risk; On-pump; Coronary artery surgery; | |
Others : 804519 DOI : 10.1186/1749-8090-9-105 |
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received in 2014-02-02, accepted in 2014-06-13, 发布年份 2014 | |
【 摘 要 】
Background
The aim of the present study was to evaluate and compare postoperative short-term, mid-term and long-term outcomes of coronary artery bypass surgery performed with or without cardiopulmonary bypass in patients with a low European System for Cardiac Operative Risk Evaluation score.
Methods
A retrospective analysis of 478 consecutive low risk patients undergoing coronary bypass surgery between January 2002 and December 2007 was performed. Of these patients, 83 cases had undergone on-pump and 395 cases had undergone off-pump coronary bypass surgery. The patients were assessed in terms peri-operative complications, survival, mortality due to cardiac events, need for rehospitalization and repeated coronary revascularization.
Results
There was no significant difference between the two groups in terms of preoperative characteristics, except for chronic obstructive pulmonary disease. The number of distal anastomosis per patient was significantly lower in the off-pump group than in the on-pump group (2.66 ± 0.74 vs. 3.21 ± 0.85, p < 0.001). Early mortality rates were similar in both groups (1.01% for the off-pump group and 1.2% for the on-pump group, p = 0.687). Neurological complications were significantly lower in the off-pump group than in the on-pump group (1.1% vs. 6%, p = 0.01). The mean follow-up period was 80 ± 19.1 months (range, 3–112 months). The need for revascularization during long-term follow-up was 10.1% in the off-pump group and 7.2% in the on-pump group (p = 0.416). The 5-year survival was 95.2 ± 1.1% and 95.5 ± 2.7% in the off-pump and on-pump groups, respectively (p = 0.8), whereas the 7-year survival was 91.9 ± 1.6% and 84.7 ± 6.8% in the off-pump and on-pump groups, respectively (p = 0.274). The 5-year revascularization-free period was 89.5 ± 1.6% and 89.7 ± 3.5% in the off-pump and on-pump groups, respectively (p = 0.785). The 7-year revascularization-free period was 71.1 ± 3.1% and 73.5 ± 7.3% in the off-pump and on-pump groups, respectively (p = 0.075). The 7-year event-free survival was 80.1 ± 2.2% and 73.4 ± 7.3% in the off-pump and on-pump groups, respectively (p = 0.377).
Conclusions
The present study demonstrated that off-pump cardiac surgery had advantages over on-pump cardiac surgery in the short term; however, both interventions had similar mid-term and long-term outcomes, when performed in low-risk patient.
【 授权许可】
2014 Ercan et al.; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
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20140708062747473.pdf | 391KB | download |
【 参考文献 】
- [1]Mack MJ, Brown PP, Kugelmass AD, Battaglia SL, Tarkington LG, Simon AW, Culler SD, Becker ER: Current status and outcomes of coronary revascularization 1999 to 2002: 148,396 surgical and percutaneous procedures. Ann Thorac Surg 2004, 77:761-766. discussion 766–8
- [2]Afilalo J, Rasti M, Ohayon SM, Shimony A, Eisenberg MJ: Off-pump vs. on-pump coronary artery bypass surgery: an updated meta-analysis and meta-regression of randomized trials. Eur Heart J 2012, 33(10):1257-1267. doi:10.1093/eurheartj/ehr307. Epub 2011 Oct 10. Review
- [3]Newman MF, Kirchner JL, Phillips-Bute B, Gaver V, Grocott H, Jones RH, Mark DB, Reves JG, Blumenthal JA, Neurological Outcome Research Group and the Cardiothoracic Anesthesiology Research Endeavors Investigators: Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. N Engl J Med 2001, 344:395-402.
- [4]Buffolo E, de Andrade CS, Branco JN, Teles CA, Aguiar LF, Gomes WJ: Coronary artery bypass grafting without cardiopulmonary bypass. Ann Thorac Surg 1996, 61:63-66.
- [5]Nathoe HM, van Dijk D, Jansen EW, Suyker WJ, Diephuis JC, van Boven WJ, de la Rivière AB, Borst C, Kalkman CJ, Grobbee DE, Buskens E, de Jaegere PP, Octopus Study Group: A comparison of on-pump and off-pump coronary bypass surgery in low-risk patients. N Engl J Med 2003, 348:394-402.
- [6]Geissler HJ, Hölzl P, Marohl S, Kuhn-Régnier F, Mehlhorn U, Südkamp M, de Vivie ER: Risk stratification in heart surgery: comparison of six score systems. Eur J Cardiothorac Surg 2000, 17:400-406.
- [7]Thygesen K, Alpert JS, White HD: Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction. Eur Heart J 2007, 28(20):2525-2538.
- [8]Cheng DC, Bainbridge D, Martin JE, Novick RJ, Evidence-Based Perioperative Clinical Outcomes Research Group: Does off-pump coronary artery bypass reduce mortality, morbidity, and resource utilization when compared with conventional coronary artery bypass? A meta-analysis of randomized trials. Anesthesiology 2005, 102:188-203.
- [9]Wijeysundera DN, Beattie WS, Djaiani G, Rao V, Borger MA, Karkouti K, Cusimano RJ: Off-pump coronary artery surgery for reducing mortality and morbidity: meta-analysis of randomized and observational studies. J Am Coll Cardiol 2005, 46:872-882.
- [10]van Dijk D, Nierich AP, Jansen EW, Nathoe HM, Suyker WJ, Diephuis JC, van Boven WJ, Borst C, Buskens E, Grobbee DE, Robles De Medina EO, de Jaegere PP, Octopus Study Group: Early outcome after off-pump versus on-pump coronary bypass surgery: results from a randomized study. Circulation 2001, 104:1761-1766.
- [11]Sabik JF, Gillinov AM, Blackstone EH, Vacha C, Houghtaling PL, Navia J, Smedira NG, McCarthy PM, Cosgrove DM, Lytle BW: Does off-pump coronary surgery reduce morbidity and mortality? J Thorac Cardiovasc Surg 2002, 124:698-707.
- [12]Khan NE, De Souza A, Mister R, Flather M, Clague J, Davies S, Collins P, Wang D, Sigwart U, Pepper J: A randomized comparison of off-pump and on-pump multivessel coronary-artery bypass surgery. N Engl J Med 2004, 350:21-28.
- [13]Angelini GD, Taylor FC, Reeves BC, Ascione R: Early and midterm outcome after off-pump and on-pump surgery in Beating Heart Against Cardioplegic Arrest Studies (BHACAS 1 and 2): a pooled analysis of two randomised controlled trials. Lancet 2002, 359:1194-1199.
- [14]Edelman JJ, Yan TD, Bannon PG, Wilson MK, Vallely MP: Coronary artery bypass grafting with and without manipulation of the ascending aorta - a meta-analysis. Heart Lung Circ 2011, 20:318-324.
- [15]Reston JT, Tregear SJ, Turkelson CM: Meta‒analysis of short‒term and mid‒term outcomes following off‒pump coronary artery bypass grafting. Ann Thorac Surg 2003, 76(5):1510-1515.
- [16]Puskas JD, Williams WH, Duke PG, Puskas JD, Williams WH, Duke PG, Staples JR, Glas KE, Marshall JJ, Leimbach M, Huber P, Garas S, Sammons BH, McCall SA, Petersen RJ, Bailey DE, Chu H, Mahoney EM, Weintraub WS, Guyton RA: Off-pump coronary artery bypass grafting provides complete revascularization with reduced myocardial injury, transfusion requirements, and length of stay: a prospective randomized comparison of two hundred unselected patients undergoing off-pump versus. conventional coronary artery bypass grafting. J Thorac Cardiovasc Surg 2003, 125:797-808.
- [17]Puskas JD, Williams WH, Mahoney EM, Huber PR, Block PC, Duke PG, Staples JR, Glas KE, Marshall JJ, Leimbach ME, McCall SA, Petersen RJ, Bailey DE, Weintraub WS, Guyton RA: Off-pump vs conventional coronary artery bypass grafting: early and 1-year graft patency, cost, and quality-of- life outcomes: a randomized trial. JAMA 2004, 291:1841-1849.
- [18]Roach GW, Kanchuger M, Mangano CM, Newman M, Nussmeier N, Wolman R, Aggarwal A, Marschall K, Graham SH, Ley C: Adverse cerebral outcomes after coronary bypass surgery. Multicenter Study of Perioperative Ischemia Research Group and the Ischemia Research and Education Foundation Investigators. N Engl J Med 1996, 335:1857-1863.
- [19]Newman MF, Grocott HP, Mathew JP, White WD, Landolfo K, Reves JG, Laskowitz DT, Mark DB, Blumenthal JA, Neurologic Outcome Research Group and the Cardiothoracic Anesthesia Research Endeavors (CARE) Investigators of the Duke Heart Center: Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery. Stroke 2001, 32:2874-2881.
- [20]Gardner TJ, Horneffer PJ, Manolio TA, Pearson TA, Gott VL, Baumgartner WA, Borkon AM, Watkins L Jr, Reitz BA: Stroke following coronary artery bypass grafting: a ten-year study. Ann Thorac Surg 1985, 40:574-581.
- [21]Frye RL, Kronmal R, Schaff HV, Myers WO, Gersh BJ: Stroke in coronary artery bypass graft surgery: an analysis of the CASS experience. The participants in the Coronary Artery Surgery Study. Int J Cardiol 1992, 36:213-221.
- [22]Kim KB, Kang CH, Chang WI, Lim C, Kim JH, Ham BM, Kim YL: Off-pump coronary artery bypass with complete avoidance of aortic manipulation. Ann Thorac Surg 2002, 74:S1377-S1382.
- [23]Murkin JM: Hemodynamic changes during cardiac manipulation in off-CPB surgery: relevance in brain perfusion. Heart Surg Forum 2002, 5:221-224.
- [24]Ascione C, Lloyd CT, Underwood MJ, Gomes WJ, Angelini GD: On-pump versus off-pump coronary revascularization: evaluation of renal function. Ann Thorac Surg 1999, 68:493-498.
- [25]Fortescue EB, Bates DW, Chertow GM: Predicting acute renal failure after coronary bypass surgery: cross-validation of two risk-stratification algorithms. Kidney Int 2000, 57:2594-2602.
- [26]Hickey P, Buckley M, Philibin D: Pulsatile and nonpulsatile cardiopulmonary bypass: review of a counterproductive controversy. Ann Thorac Surg 1983, 36:720-737.
- [27]Angelini GD, Culliford L, Smith DK, Hamilton MC, Murphy GJ, Ascione R, Baumbach A, Reeves BC: Effects of on- and off-pump coronary artery surgery on graft patency, survival, and health-related quality of life: long-term follow-up of 2 randomized controlled trials. J Thorac Cardiovasc Surg 2009, 137:295-303.
- [28]Parolari A, Alamanni F, Polvani G, Agrifoglio M, Chen YB, Kassem S, Veglia F, Tremoli E, Biglioli P: Meta-analysis of randomized trials comparing off-pump with on-pump coronary artery bypass graft patency. Ann Thorac Surg 2005, 80:2121-2125.
- [29]Takagi H, Matsui M, Umemoto T: Off-pump coronary artery bypass may increase late mortality: a meta-analysis of randomized trials. Ann Thorac Surg 2010, 89:1881-1888.