MicroRNAs and ovarian function

Journal of Ovarian Research

Julang Li¹  Jason Baley¹ 

[1] Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada

关键词: small RNA;    ovaries;    gene regulation;    microRNA;   

Others  :  815144
DOI  :  10.1186/1757-2215-5-8

 received in 2011-11-29, accepted in 2012-02-09,  发布年份 2012

【 摘 要 】

MicroRNAs (miRNAs) are a class of small non-coding RNAs which function in gene regulation with an important role in cell proliferation, maturation, and activity. The regulatory role of these small RNA molecules has recently begun to be explored in ovarian cells, uncovering their influence on gonadal development, steroidogenesis, apoptosis, ovulation, and corpus luteum development. This emerging area of research has extended and reshaped our understanding on how ovarian function is regulated. Here, we review the current understanding of miRNA biogenesis, the role and mechanism that miRNAs play in post-transcriptional gene expression regulation, and specifically the current evidence of miRNA involvement in ovarian development and function. Future comprehensive understanding of the role of miRNAs in the ovary in both physiological and pathological conditions may offer new treatment strategies for infertility and other ovarian disorders.

【 授权许可】

   
2012 Baley and Li; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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