Psychometric properties of the disease-specific health-related quality of life instrument VascuQoL in a Swedish setting

Health and Quality of Life Outcomes

Christine Wann-Hansson²  Monica Pettersson³  Jan Karlsson¹  Joakim Nordanstig⁴ 

[1] Centre for Health Care Sciences, Örebro University Hospital, Örebro, Sweden;Department for Vascular Disease, Skåne University Hospital and Faculty of Health and Society, Malmö University, Malmö, Sweden;Institute of Health and Care Sciences, Sahlgrenska University Hospital and Academy, Gothenburg, Sweden;Department of Vascular Surgery and Institute of Medicine, Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, Bruna Stråket 11 B, 413 45, Gothenburg, Sweden

关键词: Psychometric validation;    Intermittent claudication;    Peripheral arterial disease;    Health-related quality of life;    Patient-reported outcome measures;   

Others  :  825692
DOI  :  10.1186/1477-7525-10-45

 received in 2012-01-12, accepted in 2012-04-09,  发布年份 2012

【 摘 要 】

Background

Traditional outcome measures in peripheral arterial disease (PAD) provide insufficient information regarding patient benefit. It has therefore been suggested to add patient-reported outcome measures. The main aim of this study was to validate the Swedish Vascular Quality of Life questionnaire (VascuQoL) version, a patient-reported PAD-specific health-related quality of life (HRQoL) instrument.

Methods

Two-hundred PAD patients were consecutively recruited from two university hospitals. Out of the 200 subjects, 129 had intermittent claudication and 71 had critical limb ischemia. Mean age was 70 ± 9 y and 57% of the participants were male. All patients completed SF-36 and VascuQoL at the vascular outpatient clinic, when evaluated for invasive treatment. Risk factors and physiological parameters were registered. Construct validity was tested by correlation analysis versus SF-36 and was also assessed with multitrait/multi-item scaling analysis (MTMI). Sensitivity analysis regarding disease severity identification was performed. Reliability was assessed with Cronbach's alpha and responsiveness by standardized response mean (SRM) calculations.

Results

Significant correlations were demonstrated between relevant subscales of VascuQoL and SF-36. MTMI showed acceptable construct validity, but some scaling-errors. VascuQoL significantly (p < 0.001) discriminated claudicants from critical limb ischemia patients. Cronbach's alpha was 0.94 and SRM 1.02 (sum score).

Conclusions

The Swedish version of VascuQoL is valid and quantifies central aspects of HRQoL in PAD patients. Sensitivity analysis showed high ability to differentiate between disease severity and SRM illustrated excellent responsiveness. The relative abundance of items however makes use in the everyday clinical setting somewhat difficult.

【 授权许可】

   
2012 Nordanstig et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1 .

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