Sorting nexin 24 genetic variation associates with coronary artery aneurysm severity in Kawasaki disease patients

Cell & Bioscience

Fuu-Jen Tsai⁵  Chia-Yen Chen⁴  Kuan-Teh Jeang⁹  Hsinyi Tsang¹  Li-Ching Chang³  Chien-Hsiun Chen³  Jer-Yuarn Wu³  Jin-Hua Chen⁸  Wen-Kuei Chien⁸  Cheng-Wen Lin⁶  Chiu-Chu Liao²  Shao-Mei Huang²  Ting-Hsu Lin²  Xiang Liu⁹  Jeng-Sheng Chang⁷  Ying-Ju Lin⁵ 

[1] The Laboratory of Molecular Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA;Department of Medical Research, China Medical University Hospital, Taichung, Taiwan;Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan;Viral Biochemistry Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA;School of Chinese Medicine, China Medical University, Taichung, Taiwan;Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan;Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan;Biostatistics Center, Taipei Medical University, Taipei, Taiwan;Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

关键词: Polymorphism;    Sorting nexin 24;    Coronary artery aneurysm;    Kawasaki disease;   

Others  :  791435
DOI  :  10.1186/2045-3701-3-44

 received in 2013-06-27, accepted in 2013-10-09,  发布年份 2013

【 摘 要 】

Background

The sorting nexin (SNX) family is involved in endocytosis and protein trafficking and plays multiple roles in various diseases. The role of SNX proteins in Kawasaki disease (KD) is not known. We attempted to test whether genetic SNX variation associates with the risk of coronary artery aneurysm (CAA) formation in KD.

Methods and results

Chi-square tests were used to identify SNX24 genetic variants associated with KD susceptibility and CAA formation in KD; models were adjusted for fever duration and time of first administration of intravenous immunoglobulin. We obtained clinical characteristics and genotypes from KD patients (76 with CAA and 186 without CAA) in a population-based retrospective KD cohort study (n = 262). Clinical and genetic factors were associated with CAA formation in KD. In addition, endothelial cell inflammation was evaluated. Significant correlation was observed between KD with CAA complications and the rs28891 single-nucleotide polymorphism in SNX24. Patients with CC + CT genotypes had lesser CAA complications. In lipopolysaccharide-treated human umbilical vein endothelial cells, siRNA knockdown of SNX24 significantly decreased gene expression of the proinflammatory cytokines IL-1 beta, IL-6, and IL-8.

Conclusions

Polymorphisms in SNX24 may be used as genetic markers for the diagnosis and prognosis of CAA formation in KD.

【 授权许可】

   
2013 Lin et al.; licensee BioMed Central Ltd.

【 图 表 】

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