The road to clinical use of high-intensity focused ultrasound for liver cancer: technical and clinical consensus

Journal of Therapeutic Ultrasound

Wladyslaw M Gedroyc⁴  Young-sun Kim²  Andreas Melzer⁵  Lian Zhang^1,11  Feng Wu^1,13  Joo Ha Hwang^1,15  Alessandro Napoli⁷  Neal Kassell^1,10  Arik Hananel^1,10  Matt Eames^1,10  Heather Huff-Simonin^1,10  Fangwei Ye^1,16  Yerucham Shapira³  Kevin Michael Sekins^1,14  Sham Sokka⁸  Rares Salomir⁶  Mario Ries^1,12  Gail ter Haar¹  Chrit Moonen^1,12  Kim Butts Pauly⁹  Jean-Francois Aubry^1,17 

[1] Division of Radiotherapy and Imaging, The Institute of Cancer Research, Royal Marsden Hospital, Sutton, Surrey, UK;Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;InSightec Ltd, 5 Nahum Heth Street, Haifa, Israel;Saint Mary’s Hospital, Praed St, W2 1NY, London, UK;Institute for Medical Science and Technology, University of Dundee, Dundee, Scotland, UK;Faculty of Medicine, University of Geneva, Geneva, Switzerland;University of Rome, La Sapienza, Rome, Italy;Philips Healthcare, Boston, MA, USA;Radiological Sciences Laboratory, Stanford University School of Medicine, Palo Alto, CA, USA;Focused Ultrasound Foundation, Charlottesville, VA, USA;Clinical Center for Tumor Therapy, Second Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing, China;Imaging Division, University Medical Center Utrecht, Amsterdam, The Netherlands;Institute of Ultrasonic Engineering in Medicine, Chongqing Medical University, Chongqing, China;Ultrasound Innovations Applications, Siemens Healthcare, Issaquah, WA, USA;Digestive Disease Center, University of Washington, Seattle, WA, USA;Chongqing Haifu Medical Technology Co., Ltd, Chongqing, China;Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA

关键词: Liver cancer;    Focused ultrasound;    High-intensity ultrasound;    Non-invasive surgery;    Ultrasound;   

Others  :  801510
DOI  :  10.1186/2050-5736-1-13

 received in 2013-03-15, accepted in 2013-06-12,  发布年份 2013

【 摘 要 】

Clinical use of high-intensity focused ultrasound (HIFU) under ultrasound or MR guidance as a non-invasive method for treating tumors is rapidly increasing. Tens of thousands of patients have been treated for uterine fibroid, benign prostate hyperplasia, bone metastases, or prostate cancer. Despite the methods' clinical potential, the liver is a particularly challenging organ for HIFU treatment due to the combined effect of respiratory-induced liver motion, partial blocking by the rib cage, and high perfusion/flow. Several technical and clinical solutions have been developed by various groups during the past 15 years to compensate for these problems. A review of current unmet clinical needs is given here, as well as a consensus from a panel of experts about technical and clinical requirements for upcoming pilot and pivotal studies in order to accelerate the development and adoption of focused ultrasound for the treatment of primary and secondary liver cancer.

【 授权许可】

   
2013 Aubry et al.; licensee BioMed Central Ltd.

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