Muscle protein metabolism in neonatal alloxan-administered rats: effects of continuous and intermittent swimming training

Diabetology & Metabolic Syndrome

Maria AR Mello¹  Jose D Botezelli¹  Gustavo G Araújo¹  Leandro P Moura¹  Ana C Ghezzi¹  Michel B Araújo¹  Rodrigo A Dalia¹  Lucieli T Cambri¹  Carla Ribeiro¹ 

[1] São Paulo State University - UNESP, Physical Education Department, Av: 24-A, 1515 Bela Vista. CEP: 13506-900 Rio Claro - São Paulo - Brazil

关键词: hypertrophy muscle;    protein synthesis;    exercise training;    DMT2;   

Others  :  1120478
DOI  :  10.1186/1758-5996-4-5

 received in 2011-11-11, accepted in 2012-02-06,  发布年份 2012

【 摘 要 】

Background

This study aimed to examine the effects of intermittent and continuous swimming training on muscle protein metabolism in neonatal alloxan-administered rats.

Methods

Wistar rats were used and divided into six groups: sedentary alloxan (SA), sedentary control (SC), continuous trained alloxan (CA), intermittent trained alloxan (IA), continuous trained control (CC) and intermittent trained control (IC). Alloxan (250 mg/kg body weight) was injected into newborn rats at 6 days of age. The continuous training protocol consisted of 12 weeks of swimming training in individual cylinder tanks while supporting a load that was 5% of body weight; uninterrupted swimming for 1 h/day, five days a week. The intermittent training protocol consisted of 12 weeks of swimming training in individual cylinder tanks while supporting a load that was 15% of body weight; 30 s of activity interrupted by 30 s of rest for a total of 20 min/day, five days a week.

Results

At 28 days, the alloxan animals displayed higher glycemia after glucose overload than the control animals. No differences in insulinemia among the groups were detected. At 120 days, no differences in serum albumin and total protein among the groups were observed. Compared to the other groups, DNA concentrations were higher in the alloxan animals that were subjected to continuous training, whereas the DNA/protein ratio was higher in the alloxan animals that were subjected to intermittent training.

Conclusion

It was concluded that continuous and intermittent training sessions were effective in altering muscle growth by hyperplasia and hypertrophy, respectively, in alloxan-administered animals.

【 授权许可】

   
2012 Ribeiro et al; licensee BioMed Central Ltd.

【 图 表 】

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