Metabolomic profiling in blood from umbilical cords of low birth weight newborns

Journal of Translational Medicine

Empar Lurbe³  José Manuel Morales¹  Daniel Monleón⁴  Felipe Javier Chaves²  Consuelo García-Vicent⁵  Carmen Ivorra⁶ 

[1] Unidad Central Investigación Medicina, Universidad de Valencia /INCLIVA, Av. Blasco Ibáñez, 17, Valencia, 46014, Spain;CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Madrid, Spain;Department of Pediatrics, Consorcio Hospital General, University of Valencia, Av. Tres Cruces s/n, Valencia, 46014, Spain;Fundación Investigación Hospital Clínico Universitario de Valencia / INCLIVA, Av. Blasco Ibáñez, 17, Valencia, Spain;Cardiovascular Risk Unit, Consorcio, Hospital General, University of Valencia, Av. Tres Cruces s/n, Valencia 46014, Spain;CIBER Fisiopatología Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III, Madrid, Spain

关键词: Fetal factors;    Amino acids;    Metabolomics;    Umbilical cord;    Low birth weight;   

Others  :  1205939
DOI  :  10.1186/1479-5876-10-142

 received in 2012-04-03, accepted in 2012-06-13,  发布年份 2012

【 摘 要 】

Background

Low birth weight has been linked to an increased risk to develop obesity, type 2 diabetes, and hypertension in adult life, although the mechanisms underlying the association are not well understood. The objective was to determine whether the metabolomic profile of plasma from umbilical cord differs between low and normal birth weight newborns.

Methods

Fifty healthy pregnant women and their infants were selected. The eligibility criteria were being born at term and having a normal pregnancy. Pairs were grouped according to their birth weight: low birth weight (LBW, birth weight < 10^th percentile, n = 20) and control (control, birth weight between the 75^th-90^th percentiles, n = 30). Nuclear Magnetic Resonance (NMR) was used to generate metabolic fingerprints of umbilical cord plasma samples. Simultaneously, the metabolomic profiles of the mothers were analysed. The resulting data were subjected to chemometric, principal component and partial least squares discriminant analyses.

Results

Umbilical cord plasma from LBW and control newborns displayed a clearly differentiated metabolic profile. Seven metabolites were identified that discriminate the LBW from the control group. LBW newborns had lower levels of choline, proline, glutamine, alanine and glucose than did the control newborns, while plasma levels of phenylalanine and citrulline were higher in LBW newborns (p < 0.05). No significant differences were found between the two groups of mothers.

Conclusions

Low birth weight newborns display a differential metabolomic profile than those of normal birth weight, a finding not present in the mothers. The meaning and the potential utility of the findings as biomarkers of risk need to be addressed in future studies.

【 授权许可】

   
2012 2012 Ivorra et al.; licensee BioMed Central Ltd.

【 图 表 】

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