Transient elastography discloses identical distribution of liver fibrosis in chronic hepatitis C between HIV-negative and HIV-positive patients on HAART

European Journal of Medical Research

U Spengler³  T Sauerbruch³  J Oldenburg²  F Lammert¹  J Rockstroh³  G Goldmann²  N Vidovic²  S Herkenrath³  J-C Wasmuth³  F Grünhage¹ 

[1] Department of Internal Medicine II, Saarland University Hospital, Homburg, Germany;Institute for Experimental Hemostasiology and Transfusion Medicine, University Hospital Bonn, Bonn, Germany;Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany

关键词: transelastography;    HCV;    HIV;    Liver fibrosis;   

Others  :  1093262
DOI  :  10.1186/2047-783X-15-4-139

 received in 2009-11-03, accepted in 2009-12-07,  发布年份 2010

【 摘 要 】

Objective

Progressive immunodeficiency associated with HIV-infection leads to a progressive course of liver disease in HIV/HCV-co-infected patients. Highly active antiretroviral therapy (HAART) efficiently restores and preserves immune functions and has recently been demonstrated to also result in reduced liver-related mortality in HIV/HCV-co-infected patients.

Methods

To analyse differences in current liver fibrosis as a possible effect of HAART on fibrosis progression we assessed hepatic fibrosis by transient elastography in a cross-sectional comparison between HCV-mono-infected and HIV/HCV-co-infected patients presenting at our outpatient department in 2007.

Results

Overall, we did not find any difference in the distribution of liver stiffness between mono- (n = 84) and double-infected (n = 57) patients (14.4 kPa (10.8 - 18.2) versus 12.4 kPa (9.1 - 16.1), mean (95%-CI)). However, in the 8 HIV+ patients with CD4 counts < 200/μl liver stiffness was markedly greater (18.4 kPa (0.8 - 36.0)) than in HIV+ patients with preserved immunity (11.5 kPa (8.4 - 15.0)).

Conclusions

These findings are in line with other data that show an improved prognosis of chronic hepatitis C in HIV+ patients under effective HAART, and may be a hint that fibrosis progression in well-treated HIV+ patients will no longer be different from that in HCV-mono-infected patients.

【 授权许可】

   
2010 I. Holzapfel Publishers

【 图 表 】

Figure 1.

Figure 2.

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