Docosahexaenoic acid in maternal and neonatal plasma phospholipids and milk lipids of Taiwanese women in Kinmen: fatty acid composition of maternal blood, neonatal blood and breast milk

Lipids in Health and Disease

Robert H Glew²  Chiu-Ping Lin⁴  Hsi-Hsin Li¹  Lu-Te Chuang⁵  Hsiao-Ling Huang³ 

[1] Department of Surgery, Kinmen Hospital, Kinmen, Taiwan;Department of Surgery, School of Medicine, University of New Mexico, Albuquerque, NM, USA;Department of Healthcare Management, Yuanpei University, Hsinchu, Taiwan;Department of Gynecology, Kinmen Hospital, Kinmen, Taiwan;Department of Biotechnology, Yuanpei University, Hsinchu, Taiwan

关键词: Fatty acids;    Pregnancy;    Docosahexaenoic acid;    Kinmen;    Fish intake;    Neonates;    Lactation;    Breast milk;   

Others  :  1160060
DOI  :  10.1186/1476-511X-12-27

 received in 2012-12-10, accepted in 2013-02-28,  发布年份 2013

【 摘 要 】

Background

Docosahexaenoic acid (DHA) is a long-chain omega-3 polyunsaturated fatty acid (LCPUFA) that is critically important for the structure, development and function of the retina and central nervous system (CNS), ultimately contributing to improved cognition. It is known that the DHA content of breast milk is positively correlated with maternal DHA intake. Since there is a lack of information about the DHA status of pregnant and lactating women in rural Taiwan. The aims of the present study were to: 1) assess the DHA status of mothers and babies in urban setting, and 2) determine the content of DHA in the milk of nursing mothers.

Methods

All pregnant women who attended the Obstetrics and Gynecology Outpatient Clinic of Kinmen Hospital on Kinmen Island in Taiwan between May 1 and May 30, 2011 were invited by research nurses to enroll in the study. The maternal blood sample was obtained on the day of their delivery. Cord blood was collected by the obstetrician following delivery. Participants were asked to visit the doctor forty-two days after the delivery, at which time a nurse collected breast milk on the day mothers were visiting the doctor for post-natal well-baby check-up.

Results

The DHA percentages of maternal and neonatal plasma phospholipids were 5.16% and 6.36%, respectively, which are higher than values reported for most populations elsewhere in the world. The DHA percentage for the breast milk of Kinmen mothers was also high (0.98%) relation to international norms. The DHA proportions in maternal and neonatal plasma phospholipids were positively correlated (r = 0.46, p = 0.01).

Conclusions

We show that the DHA status of mothers and newborns on Kinmen Island is satisfactory, thereby providing an evidence-based argument for promoting breastfeeding in Taiwan.

【 授权许可】

   
2013 Huang et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Crawford M, Hassan AG, Williams G: Essential fatty acids and brain growth. Lancet 1976, 28:452-453.
• [2]Morale SE, Hoffman DR, Casteneda YS, Wheaton DH, Burns RA, Birch EE: Duration of long-chain polyunsaturated fatty acids availability in the diet and visual acuity. Early Hum Dev 2005, 81:197-203.
• [3]SanGiovanni JP, Berkey CS, Dwyer JT, Colditz GA: Dietary essential fatty acids, long-chain polyunsaturated fatty acids, and visual resolution acuity in healthy fullterm infants: a systematic review. Early Hum Dev 2000, 57:165-188.
• [4]Uauy R, Hoffman DR, Mena P, Llanos A, Birch EE: Term infant studies of DHA and ARA supplementation on neurodevelopment: results of randomized controlled trials. J Pediatr 2003, 143:s17-s25.
• [5]Koletzko B, Mrotzek M, Bremer HJ: Fatty acid composition of mature human milk in Germany. Am J Clin Nutr 1988, 47:954-959.
• [6]Bergmann RL, Haschke-Becher E, Klassen-Wigger P, Bergmann KE, Richter R, Dudenhausen JW, Grathwohl D, Haschke F: Supplementation with 200 mg/day docosahexaenoic acid from mid-pregnancy through lactation improves the docosahexaenoic acid status of mothers with a habitually low fish intake and of their infants. Ann Nutr Metab 2008, 52:157-166.
• [7]Damsgaard CT, Lauritzen L, Kjaer TM, Holm PM, Fruekilde MB, Michaelsen KF, Frøkiaer H: Fish oil supplementation modulates immune function in healthy infants. J Nutr 2007, 137:1031-1036.
• [8]Bakker EC, Hornstra G, Blanco C, Vles JS: Relationship between long-chain polyunsaturated fatty acids at birth and motor function at 7 years of age. Eur J Clin Nutr 2009, 63:499-504.
• [9]Boucher O, Burden MJ, Muckle G, Saint-Amour D, Ayotte P, Dewailly E, Nelson CA, Jacobson SW, Jacobson JL: Neurophysiologic and neurobehavioral evidence of beneficial effects of prenatal omega-3 fatty acid intake on memory function at school age. Am J Clin Nutr 2011, 93:1025-1037.
• [10]Cheatham CL, Colombo J, Carlson SE: 3 Fatty acids and cognitive and visual acuity development: methodologic and conceptual considerations. Am J Clin Nutr 2006, 83:s1458-s1466.
• [11]Cheruku SR, Montgomery-Downs HE, Farkas SL, Thoman EB, Lammi-Keefe CJ: Higher maternal plasma DHA during pregnancy is associated with more mature neonatal sleep-state patterning. Am J Clin Nutr 2002, 76:608-613.
• [12]Jacobson JL, Jacobson SW, Muckle G, Kaplan-Estrin M, Ayotte P, Dewailly E: Beneficial effects of a polyunsaturated fatty acid on infant development evidence from the Inuit of Arctic Quebec. J Pediatr 2008, 152:356-364.
• [13]Jacques C, Levy E, Muckle G, Jacobson SW, Bastien C, Dewailly E, Ayotte P, Jacobson JL, Saint-Amour D: Long-term effects of prenatal omega-3 fatty acid intake on visual function in school-age children. J Pediatr 2001, 158:83-90.
• [14]Kannass KN, Colombo J, Carlson SE: Maternal DHA levels and toddler free-play attention. Dev Neuropsychol 2009, 34:159-174.
• [15]Krabbendam L, Bakker E, Hornstra G, van Os J: Relationship between DHA status at birth and child problem behaviour at 7 years of age. Prostaglandins Leukot Essent Fatty Acids 2007, 76:29-34.
• [16]Mendez MA, Torrent M, Julvez J, Ribas-Fitó N, Kogevinas M, Sunyer J: Maternal fish and other seafood intakes during pregnancy and child neurodevelopment at age 4 years. Public Health Nutr 2009, 12:1702-1710.
• [17]Gibson RA, Neumann MA, Makrides M: Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte fatty acids and neural indices in exclusively breast fed infants. Eur J Clin Nutr 1997, 51:578-584.
• [18]World Health Organization: Global strategy for infant and young child feeding. Geneva: World Health Organization; 2003.
• [19]World Health Organization: UNICEF and Wellstart International. Baby-friendly hospital initiative: revised, updated and expanded for integrated care. Section 3, Breastfeeding promotion and support in a baby-friendly hospital: a 20-hour course for maternity staffhttp://www.who.int/nutrition/publications/infantfeeding/9789241594981_s3/en/ webcite
• [20]Chen CH, Chi CS: Maternal intention and actual behavior in infant feeding at one month postpartum. Acta Paediatr Taiwanica 2003, 44:140-144.
• [21]Lin CC, Chen SH: The effects of nursing guidance on the breastfeeding patterns, knowledge and attitudes of foreign spouses. Journal of Evidence-Based Nursing 2007, 3:161-169. (In Chinese)
• [22]Teng SW, Chang M, Yang YL: An exploration on the factors influencing the mother's breast-feeding attitude and feeding method after delivery. Chin J Public Health 1997, 16:13-23.
• [23]Peng Y, Zhou T, Wang Q, Liu P, Zhang T, Zetterstrom R, Strandvik B: Fatty acid composition of diet, cord blood and breast milk in Chinese mothers with different dietary habits. Prostaglandins Leukot Essent Fatty Acids 2009, 81:325-330.
• [24]Meyer BJ, Kolanu N: Australian children are not consuming enough long-chain omega-3 polyunsaturated fatty acids for optimal health. Nutrition 2011, 27:1136-1140.
• [25]Loy SL, Marhazlina M, Nor AY, Hamid JJ: Development, validity and reproducibility of a food frequency questionnaire in pregnancy for the Universiti Sains Malaysia birth cohort study. Malayas J Nutr 2011, 17:1-18.
• [26]Mouratidou T, Ford F, Fraser RB: Validation of a food-frequency questionnaire for use in pregnancy. Public Health Nutr 2006, 9:515-522.
• [27]Willett WC, Sampson L, Stampfer MJ, Rosner B, Bain C, Witschi J, Hennekens CH, Speizer FE: Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol 1985, 122:51-65.
• [28]Tseng LH, Tung HH, Wei J, Chang CY, Chen YC: An investigation of the diet preferences of patients with metabolic syndrome who underwent coronary artery bypass graft surgery. Hu Li Za Zhi 2011, 58:64-73. (In Chinese)
• [29]Folch J, Lees M, Stanley GH: A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957, 226:497-509.
• [30]Brenna JT, Varamini B, Jensen RG, Diersen-Schade DA, Boettcher JA, Arterburn LM: Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr 2007, 85:1457-1464.
• [31]Innis SM: Fatty acids and early human development. Early Hum Dev 2007, 83:761-766.
• [32]Clandinin MT, Chappell JE, Leong S, Heim T, Swyer PR, Chance GW: Intrauterine fatty acid accretion rates in human brain: implications for fatty acid requirements. Early Hum Dev 1980, 4:121-129.
• [33]Martinez M: Tissue levels of polyunsaturated fatty acids during early development. J Pediatr 1992, 120:s129-s138.
• [34]Helland IB, Saugstad OD, Saarem K, Van Houwelingen AC, Nylander G, Drevon CA: Supplementation of n-3 fatty acids during pregnancy and lactation reduces maternal plasma lipid levels and provides DHA to the infants. J Matern Fetal Neonatal Med 2006, 19:397-406.
• [35]Ollis TE, Meyer BJ, Howe PRC: Australian food sources and intakes of omega-6 and omega-3 polyunsaturated fatty acids. Ann Nutr Metab 1999, 43:346-355.
• [36]Makrides M, Neumann M, Zimmer K, Pater J, Gibson R: Are long-chain fatty polyunsaturated fatty essential nutrients in infancy? Lancet 1995, 345:1463-1468.
• [37]Bjerve KS, Brubakk AM, Fougner KJ, Johnsen H, Midthjell K, Vik T: Omega-3 fatty acids: essential fatty acids with important biological effects, and plasma phospholipid fatty acids as markers of dietary omega 3-fatty acid intake. Am J Clin Nutr 1993, 57:s801-s805.
• [38]van Eijsden M, Hornstra G, van der Wal MF, Bonsel GI: Ethnic differences in early pregnancy maternal n-3 and n-6 fatty acid concentrations: an explorative analysis. Br J Nutr 2009, 101:1761-1768.
• [39]Sabel K-G, Lundqvist-Persson C, Bona E, Petzold M, Strandvik B: Fatty acid patterns early after premature birth, simultaneously analyzed in mothers’ food, breast milk and plasma phospholipids of mothers and infants. Lipids Health Dis 2009, 8:20. BioMed Central Full Text
• [40]Laitinen K, Sallinen J, Isolauri LK: Plasma, cheek cell and breast milk fatty acid compositions in infants with atopic and no-topic eczema. Clin Exp Allergy 2006, 36:166-173.
• [41]Peng YM, Zhang TY, Wang Q, Zetterstrom R, Strandvik B: Fatty acid composition in breast milk and plasma phospholipids of health term Chinese infants during first 6 weeks of life. Acta Paediatr 2007, 96:1640-1645.
• [42]Socha P, Koletzko B, Swiatkowska E, Pawlowska J, Stolarczyk A, Socha J: Essential fatty acid metabolism in infants with cholestasis. Acta Paediatr 1998, 87:278-283.
• [43]Food and Agriculture Organization(FAO) and World Health Organization (WHO): Interim Summary of Conclusions and Dietary Recommendations on Total Fat & Fatty Acids. Geneva: From the Joint FAO/WHO Expert Consultation on Fats and Fatty Acids in Human Nutrition; Intenet: http://www.who.int/nutrition/topics/FFA_summary_rec_conclusion.pdf webcite
• [44]Meneses F, Torres AC, Trugo NMF: Essential and long-chain polyunsaturated fatty acid status and fatty acid composition of breast milk of lactating adolescents. Br J Nutr 2008, 100:1029-1037.
• [45]Yuhas R, Pramuk K, Lien EL: Human milk fatty acid composition from nine countries varies most in DHA. Lipids 2006, 41:851-858.
• [46]Makrides M, Gibson R, McPhee A, Yelland L, Quinlivan J, Ryan P, OMInO Investigative Team: Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children. JAMA 2010, 304:1675-1683.
• [47]Bureau of Health Promotion: Breastfeeding rate investigation. Internet: http://www.bhp.doh.gov.tw/BHPNet/Web/HealthTopic/TopicArticle.aspx?id=201110060023&parentid=201110060004 webcite
• [48]The United Nations Children’s Fund (UNICEF): The challenge Overview of breastfeeding patterns. Infant feeding patterns by country. Internet: http://www.childinfo.org/breastfeeding_countrydata.php?q=printme webcite Global Data Base on Breastfeeding from World Health Organization