NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax

Diagnostic Pathology

Tadashi Hasegawa³  Noriyuki Sato¹  Masato Nakayama²  Kazuyoshi Okumura²  Masaki Murata¹  Akira Takasawa¹  Tomohide Tsukahara¹ 

[1] Department of Pathology, Sapporo Medical University, South-1, West-17, Chuo-ku, Sapporo, 060-8556, Japan;Department of Surgery, Tenshi Hospital, North-12, East-3, Higashi-ku, Sapporo, 065-0012, Japan;Division of Clinical Pathology, Sapporo Medical University Hospital, South-1, West-16, Chuo-ku, Sapporo, 060-8543, Japan

关键词: Autopsy;    Pyothorax;    EBV;    Adrenal gland;    NK/T-cell lymphoma;   

Others  :  807978
DOI  :  10.1186/1746-1596-7-114

 received in 2012-07-31, accepted in 2012-08-26,  发布年份 2012

【 摘 要 】

Primary lymphoma of adrenal glands is rare, and non-B-cell lymphoma associated with pyothorax is also very rare. Here we report the first autopsy case of non-B-cell lymphoma in bilateral adrenal glands of a 79-year-old woman with pyothorax who had an aggressive clinical course. Immunohistochemically, tumor cells showed CD3+, CD45RO+, CD5-, CD7-, CD4-, CD8-, CD10-, CD20-, CD30-, CD79a-, CD138-, CD56-, granzyme B-, TIA-1+ and ALK-. In addition, tumor cells were strongly EBER1-positive by in situ hybridization. In genomic DNA of tumor cells, T-cell receptor rearrangements were not detected by southern blotting. We finally diagnosed this case as extranodal NK/T-cell lymphoma (nasal type).

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【 授权许可】

   
2012 Tsukahara et al.; licensee BioMed Central Ltd.

【 图 表 】

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