Incomplete recovery of mechanical and endocrine left atrial functions one month after electrical cardioversion for persistent atrial fibrillation: a pilot study

Journal of Translational Medicine

Dominique Babuty¹  Laurent Fauchier¹  Jean-Christophe Pagés²  Noura Zannad¹  Eric Piver²  Christophe Saint Etienne¹  Anne Bernard-Brunet¹ 

[1] Cardiology Department, François Rabelais University, 37020 Tours, France;Biochemistry Department, François Rabelais University, 37020 Tours, France

关键词: Atrial natriuretic peptide;    Speckle-tracking echocardiography;    Left atrial remodeling;    Electrical cardioversion;    Atrial fibrillation;   

Others  :  817901
DOI  :  10.1186/1479-5876-12-51

 received in 2013-08-24, accepted in 2014-02-18,  发布年份 2014

【 摘 要 】

Background

Restoration of the mechanical and endocrine functions of the left atrium remains controversial after electrical cardioversion treatment for persistent atrial fibrillation. The objective of the prospective study was to describe the recovery of the endocrine and mechanical functions of the left atrium.

Methods

Evaluation of left atrium recovery after electrical cardioversion by the new speckle-tracking echocardiography technique and proANP measurement.

Results

Twenty patients suffering from persistent atrial fibrillation with no alteration of left ventricular ejection fraction were prospectively evaluated at baseline and then one month later by echocardiography, measuring left atrial volume and left atrial deformation (MPALS), as well as the proANP and BNP concentrations. One month after cardioversion 10 patients remained in sinus rhythm and 10 showed recurrent atrial fibrillation. No significant differences between the two groups in terms of clinical, echocardiographic and endocrine parameters were observed at baseline evaluation. We observed a significant reduction of left atrial volume only in the sinus group, whereas restoration of the left atrial deformation was only partial (18%) in that group. By contrast, we registered no significant changes in ANP concentration at one month in either the sinus or the atrial fibrillation groups.

Conclusion

These results suggest that restoration of left atrium mechanical function is only partial one month after treatment of persistent atrial fibrillation by electrical cardioversion, whereas a significant reduction of left atrial volume was noted, explaining the remaining high level of ANP in the sinus group.

【 授权许可】

   
2014 Bernard-Brunet et al.; licensee BioMed Central Ltd.

【 图 表 】

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