Elevated CSF histamine levels in multiple sclerosis patients

Fluids and Barriers of the CNS

Yoshihiro Urade¹  Christian R Baumann³  Michael Linnebank³  Osamu Hayaishi¹  Stephan Blumenthal²  Claudio L Bassetti³  Kosuke Aritake¹  Ulf Kallweit³ 

[1] Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan;Department of Anesthesiology and Intensive Medicine, Triemli Hospital, Zurich, CH, Switzerland;Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091 Zurich, CH, Switzerland

关键词: Chronic inflammatory diseases;    Granulocyte-macrophage colony-stimulating factor;    CSF;    Histamine receptors;    Histamine;    Multiple sclerosis;   

Others  :  806651
DOI  :  10.1186/2045-8118-10-19

 received in 2012-12-03, accepted in 2013-04-22,  发布年份 2013

【 摘 要 】

Background

Histamine is an ubiquitous inflammatory mediator of numerous physiological processes. Histamine and its receptors have been implicated in multiple sclerosis (MS) disease pathogenesis. We prospectively enrolled 36 MS patients and 19 age and gender-matched healthy volunteers for cerebrospinal fluid (CSF) histamine analysis.

Findings

CSF histamine levels in MS patient samples were significantly higher (median: 35.6 pg/ml) than in controls (median: 5.5 pg/ml; Beta = 0.525, p < 0.001). In addition, histamine increased with age (Pearson’s correlation, p < 0.003).

Conclusions

Histamine may be an important factor for both the initiation and maintenance of chronic inflammatory diseases of the central nervous system. Our observation encourages a deeper investigation of the role of histamine in MS.

【 授权许可】

   
2013 Kallweit et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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