Treatments of medical complications of anorexia nervosa and bulimia nervosa

Journal of Eating Disorders

Katherine V Sachs²  Mori J Krantz³  Philip S Mehler¹ 

[1] Department of Medicine, University of Colorado Health Sciences Center, ACUTE at Denver Health, and Eating Recovery Center, 777 Bannock Street, MC4000, 80204, and 7351 E Lowry Blvd, Suite 200, Denver 80230, CO, USA;Department of Medicine, University of Colorado Health Sciences Center and ACUTE at Denver Health, 777 Bannock Street, MC4000, Denver 80204, CO, USA;Department of Cardiology, Denver Health and Department of Medicine, University of Colorado Health Sciences Center, 777 Bannock Street, MC4000, Denver 80204, CO, USA

关键词: Medical complications;    Anorexia nervosa;    Bulimia nervosa;    Treatment;   

Others  :  1181910
DOI  :  10.1186/s40337-015-0041-7

 received in 2014-12-16, accepted in 2015-02-17,  发布年份 2015

【 摘 要 】

Inherent to anorexia nervosa and bulimia nervosa are a plethora of medical complications which correlate with the severity of weight loss or the frequency and mode of purging. Yet, the encouraging fact is that most of these medical complications are treatable and reversible with definitive care and cessation of the eating-disordered behaviours. Herein, these treatments are described for both the medical complications of anorexia nervosa and those which are a result of bulimia nervosa.

【 授权许可】

   
2015 Mehler et al.; licensee BioMed Central.

【 参考文献 】

• [1]Diagnostic and statistical manual of mental disorders, fifth edition (DSM-5). American Psychiatric Association, Arlington, VA; 2013.
• [2]Dalle Grave R, Calugi S, Marchesini G. Is amenorrhea a clinically useful criterion for the diagnosis of anorexia nervosa? Behav Res Ther. 2008; 46:1290-4.
• [3]Golden NH, Jacobson MS, Schebendach J, Solanto MV, Hertz SM, Shenker IR. Resumption of menses in anorexia nervosa. Arch Pediatr Adolesc Med. 1997; 151:16-21.
• [4]Swenne I. Weight requirements for return of menstruations in teenage girls with eating disorders, weight loss and secondary amenorrhoea. Acta Paediatr. 2004; 93:1449-55.
• [5]Miller KK, Parulekar MS, Schoenfeld E, Parulekar S, Anderson E, Hubbard J et al.. Decreased leptin levels in normal weight women with hypothalamic amenorrhea: the effects of body composition and nutritional intake. J Clin Endocrinol Metab. 1998; 83:2309-12.
• [6]Warren MP, Voussoughian F, Geer EB, Hyle EP, Adberg CL, Ramos RH. Functional hypothalamic amenorrhea: hypoleptinemia and disordered eating. J Clin Endocrinol Metab. 1999; 84:873-7.
• [7]Welt CK, Chan JL, Bullen J, Murphy R, Smith P, DePaoli AM et al.. Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med. 2004; 351:987-97.
• [8]Chou SH, Chamberland JP, Liu X, Matarese G, Gao C, Stefanakis R et al.. Leptin is an effective treatment for hypothalamic amenorrhea. Proc Natl Acad Sci U S A. 2011; 108:6585-90.
• [9]Bergström I, Crisby M, Engström AM, Hölcke M, Fored M, Jakobsson Kruse P et al.. Women with anorexia nervosa should not be treated with estrogen or birth control pills in a bone-sparing effect. Acta Obstet Gynecol Scand. 2013; 92:877-80.
• [10]Bulik CM, Hoffman ER, Von Holle A, Torgersen L, Stoltenberg C, Reichborn-Kjennerud T. Unplanned pregnancy in women with anorexia nervosa. Obstet Gynecol. 2010; 116:1136-40.
• [11]Kohmura H, Miyake A, Aono T, Tanizawa O. Recovery of reproductive function in patients with anorexia nervosa: a 10-year follow-up study. Eur J Obstet Gynecol Reprod Biol. 1986; 22:293-6.
• [12]Koubaa S, Hällström T, Lindholm C, Hirschberg AL. Pregnancy and neonatal outcomes in women with eating disorders. Obstet Gynecol. 2005; 105:255-60.
• [13]Katz MG, Vollenhoven B. The reproductive endocrine consequences of anorexia nervosa. BJOG. 2000; 107:707-13.
• [14]Lucas AR, Melton LJ, Crowson CS, O’Fallon WM. Long-term fracture risk among women with anorexia nervosa: a population-based cohort study. Mayo Clin Proc. 1999; 74:972-7.
• [15]Baker D, Roberts R, Towell T. Factors predictive of bone mineral density in eating-disordered women: a longitudinal study. Int J Eat Disord. 2000; 27:29-35.
• [16]Kraeft JJ, Uppot RN, Heffess AM. Imaging findings in eating disorders. AJR Am J Roentgenol. 2013; 200:W328-35.
• [17]Grinspoon S, Thomas E, Pitts S, Gross E, Mickley D, Miller K et al.. Prevalence and predictive factors for regional osteopenia in women with anorexia nervosa. Ann Intern Med. 2000; 21:790-4.
• [18]Grinspoon S, Thomas L, Miller K, Herzog D, Klibanski A. Effects of recombinant human IGF-I and oral contraceptive administration on bone density in anorexia nervosa. J Clin Endocrinol Metab. 2002; 87:2883-91.
• [19]Golden NH, Iglesias EA, Jacobson MS, Carey D, Meyer W, Schebendach J et al.. Alendronate for the treatment of osteopenia in anorexia nervosa: a randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab. 2005; 90:3179-85.
• [20]Behre HM, Kliesch S, Leifke E, Link TM, Nieschlag E. Long-term effect of testosterone therapy on bone mineral density in hypogonadal men. J Clin Endocrinol Metab. 1997; 82:2386-90.
• [21]Fazeli PK, Wang IS, Miller KK, Herzog DB, Misra M, Lee H et al.. Teriparatide increases bone duration in adult women with anorexia nervosa. J Clin Endocrinol Metab. 2014; 99:1322-9.
• [22]Mehler PS, MacKenzie TD. Treatment of osteopenia and osteoporosis in anorexia nervosa: a systematic review of the literature. Int J Eat Disord. 2009; 42:195-201.
• [23]Miller KK, Grinspoon SK, Ciampa J, Hier J, Herzog D, Klibanski A. Medical findings in outpatients with anorexia nervosa. Arch Int Med. 2005; 165:561-6.
• [24]Krantz MJ, Gaudianni J, Johnson V, Mehler PS. Exercise Electrocardiography extinguishes persistent junctional rhythm in a patient with severe anorexia nervosa. Cardiology. 2011; 120:217-20.
• [25]Krantz MJ, Sabel A, Sagar U, Long CS, Barbey JT, White K et al.. Factors influencing qt prolongation in hospitalized patients with severe anorexia nervosa. Gen Hosp Psychiatry. 2011; 34:173-7.
• [26]Melanson EL, Donahoo WT, Krantz MJ, Poirier P, Mehler PS. Resting and ambulatory hearth rate variability in chronic anorexia nervosa. Am J Cardiol. 2004; 94:1217-20.
• [27]Oflaz S, Yucel B, Oz F, Sahin D, Ozturk N, Yaci O et al.. Assessment of myocardial damage by cardiac MRI in patients with anorexia nervosa. Int J Eat Disord. 2013; 46:862-6.
• [28]Kamal N, Chami T, Andersen A, Rosell FA, Schuster MM, Whitehead WE. Delayed gastrointestinal transit times in anorexia nervosa and bulimia nervosa. Gastroenterology. 1991; 101:1320-4.
• [29]Benini L, Todesco T, Dalle Grave R, Deiorio F, Salandini L, Vantini I. Gastric emptying in patients with restricting and binge/purging subtypes of anorexia nervosa. Am J Gastroenterol. 2004; 99:1448-54.
• [30]Olansson EA, Storsrud S, Grundin H, Isaksson M, Altval S, Simren M. Small particle size diet reducing upper gastrointestinal symptoms in patients with diabetic gastroperesis. Am J Gastroenterol. 2014; 109:375-85.
• [31]Rao AS, Camilleri M. Review article: metoclopramide and tardive dyskinesia. Aliment Pharmacol Ther. 2010; 31:11-9.
• [32]Kanji S, Stevenson A, Hutton B. Sudden cardiac death and ventricular arrhythmias associated with domperidone: evidence supporting health canada’s warning. Can J Hosp Pharm. 2014; 67:311-2.
• [33]Richards RD, Davenport K, McCallum RW. The treatment of idiopathic and diabetic gastroparesis with acute intravenous and chronic oral erythromycin. Am J Gastroenterol. 1993; 88:203-7.
• [34]Hines JR, Gore RM, Ballantyne GH. Superior mesenteric artery syndrome. Diagnostic criteria and therapeutic approaches. Am J Surg. 1984; 148:630-2.
• [35]Mehler PS, Weiner KL. Use of total parenteral nutrition in the refeeding of selected patients with severe anorexia nervosa. Int J Eat Disord. 2007; 40:285-7.
• [36]Holmes SR, Gudridge TA, Gaudiani JL, Mehler PS. Dysphagia in severe anorexia nervosa: a case report. Int J Eat Disord. 2012; 45:463-6.
• [37]Chun AB, Sokol MS, Kaye WH, Hutson WR, Wald A. Colonic and anorectal function in constipated patients with anorexia nervosa. Am J Gastroenterol. 1997; 92:1879-83.
• [38]Mehler PS, Krantz M. Anorexia nervosa medical issues. J Womens Health. 2003; 12:331-40.
• [39]Morris LG, Stephenson KE, Herring S, Marti JL. Recurrent acute pancreatitis in anorexia and bulimia. JOP. 2004; 5:231-4.
• [40]Harris RH, Sasson G, Mehler PS. Elevation of liver function tests in severe anorexia nervosa. Int J Eat Disord. 2013; 46:369-74.
• [41]Spechler SJ, Sharma P, Souza RF, Inadomi JM, Shaheen NJ. American gastrointestinal association medical position statement on the management of barrett’s esophagus. Gastroenterology. 2011; 140:1084-91.
• [42]Park KK, Tung RC, de Luzuiaga AR. Painful parotid hypertrophy with bulimia: a report of medical management. J Drugs Dermatol. 2009; 8:577-9.
• [43]Bellomo-Brandao MA, Collares EF, Da-Costa-Pinto EA. Use of erythromycin for the treatment of severe chronic constipation in children. Braz J Med Biol Res. 2003; 36:1391-6.
• [44]Berend K, de Vries AP, Gans RO. Physiological approach to assessment of acid–base disturbances. N Engl J Med. 2014; 371:1434-45.
• [45]Mascolo M, Trent S, Colwell C, Mehler PS. What the emergency department needs to know when caring for your patients with eating disorders. Int J Eat Disord. 2012; 45:977-81.
• [46]Trent SA, Moreira ME, Colwell CB, Mehler PS. Emergency department management of patients with eating disorders. Am J Emerg Med. 2013; 31:859-65.
• [47]Narayanan V, Gaudiani JL, Mehler PS. Serum albumin levels may not correlate with weight status in severe anorexia nervosa. Eat Disord. 2009; 17:322-6.
• [48]Aliti GB, Rabelo ER, Clausell N, Rohde LE, Brolo A, Beck-da-Silva L. Aggressive fluid and sodium restriction in acute decompensated heart failure: a randomized clinical trial. JAMA Intern Med. 2013; 24:1058-64.
• [49]Mori T, Kurumazuka D, Matsumooto C, Shirakawa H, Kimura S, Kitada K et al.. Dietary salt restriction activates mineralocorticoid receptor signalling in volume-overloaded heart failure. Eur J Pharmacol. 2009; 25:84-8.