An immunohistochemical study of canine spontaneous gastric polyps

Diagnostic Pathology

Fátima Gärtner¹  Cornel C?toi⁵  Augusto M Faustino³  Celso A Reis²  Alexandra Rêma³  Andreia Ferreira⁴  Marian A Taulescu⁵  Irina Amorim¹ 

[1] Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Dr. Roberto Frias s/n, Porto, 4200-465, Portugal;Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto, 4200- 319, Portugal;Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua Jorge Viterbo Ferreira nr.228, Porto, 4050-313, Portugal;Faculty of Sciences of the University of Porto (FCUP), Rua do Campo Alegre 1021/1055, Porto, 4169-007, Portugal;Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania

关键词: p53;    Ki67;    Helicobacter spp;    CDX2;    COX-2;    Canine gastric polyps;   

Others  :  1149903
DOI  :  10.1186/s13000-014-0166-z

 received in 2014-03-26, accepted in 2014-08-16,  发布年份 2014

【 摘 要 】

Background

Gastric polyps (GP) are characterised by luminal overgrowths projecting above the plane of the mucosal surface that can be classified as non-neoplastic and neoplastic lesions. In humans, recent studies have drawn attention to the malignant potential of some of these lesions. However, gastric polyps are uncommon lesions in dogs.

Findings

In this study, the presence of Helicobacter spp., the cellular proliferative activity, potential phenotypic alterations, COX-2 and p53 expression in canine spontaneous gastric polyps were investigated. The expression of these molecules was also studied in normal canine gastric mucosa in order to gain further knowledge of the significance of their loss or overexpression in gastric lesions.

Conclusions

The normal expression of almost all the factors evaluated, along with the reduced proliferative activity is strongly suggestive that, in dogs, spontaneous gastric polyps are not only a rare finding but also of benign nature.

Virtual Slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_166 webcite

【 授权许可】

   
2014 Amorim et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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