Accessible online neuroplasticity-targeted training for children with ADHD

Chinese Medicine

Rajesh Sagar²  Michael M Merzenich¹  Jyoti Mishra¹ 

[1] Brain Plasticity Institute, PositScience, San Francisco, CA 94108, USA;Department of Psychiatry, All India Institute of Medical Sciences, New Delhi 110029, India

关键词: Global mental health;    Neurotherapeutic;    Neuroplasticity;    Cognitive training;    ADHD;    Attention Deficit Hyperactivity Disorder;   

Others  :  790681
DOI  :  10.1186/1753-2000-7-38

 received in 2013-10-22, accepted in 2013-11-11,  发布年份 2013

【 摘 要 】

Childhood Attention Deficit Hyperactivity Disorder (ADHD) is a growing mental health concern worldwide. Effective, accessible and low-cost therapeutics for the disorder are urgently needed. Here we introduce a novel internet-based cognitive training intervention: Online Neuroplasticity-based Training for the Remediation of ADHD in Children (ONTRAC). The intervention is deployed in the home setting; it is customized to the cognitive capacities of each child and progressively improves performance in the specific neuro-cognitive domains deficient in ADHD. A feasibility trial of ONTRAC is being conducted in a resource limited clinical setting in New Delhi, India and is an exemplar of hi-tech global psychiatry.

【 授权许可】

   
2013 Mishra et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Froehlich TE, Lanphear BP, Epstein JN, Barbaresi WJ, Katusic SK, Kahn RS: Prevalence, recognition, and treatment of attention-deficit/hyperactivity disorder in a national sample of US children. Arch Pediatr Adolesc Med 2007, 161:857-864.
• [2]Perou R, Bitsko RH, Blumberg SJ, Pastor P, Ghandour RM, Gfroerer JC, Hedden SL, Crosby AE, Visser SN, Schieve LA, Parks SE, Hall JE, Brody D, Simile CM, Thompson WW, Baio J, Avenevoli S, Kogan MD, Huang LN: Mental health surveillance among children–United States, 2005–2011. MMWR Surveill Summ 2013, 62(Suppl 2):1-35.
• [3]Mukhopadhyay M, Misra S, Mitra T, Niyogi P: Attention deficit hyperactivity disorder. Indian J Pediatr 2003, 70:789-792.
• [4]Attention Deficit/ Hyperactivity Disorder. [http://www.dsm5.org/Documents/ADHD%20Fact%20Sheet.pdf webcite]
• [5]Spiller HA, Hays HL, Aleguas A: Overdose of drugs for attention-deficit hyperactivity disorder: clinical presentation, mechanisms of toxicity, and management. CNS Drugs 2013, 27:531-543.
• [6]Dopheide JA, Pliszka SR: Attention-deficit-hyperactivity disorder: an update. Pharmacotherapy 2009, 29:656-679.
• [7]Remschmidt H: Global consensus on ADHD/HKD. Eur Child Adolesc Psychiatry 2005, 14:127-137.
• [8]Molina BSG, Hinshaw SP, Swanson JM, Arnold LE, Vitiello B, Jensen PS, Epstein JN, Hoza B, Hechtman L, Abikoff HB, Elliott GR, Greenhill LL, Newcorn JH, Wells KC, Wigal T, Gibbons RD, Hur K, Houck PR: The MTA at 8 years: prospective follow-up of children treated for combined-type ADHD in a multisite study. J Am Acad Child Adolesc Psychiatry 2009, 48:484-500.
• [9]Saxena S, Thornicroft G, Knapp M, Whiteford H: Resources for mental health: scarcity, inequity, and inefficiency. Lancet 2007, 370:878-889.
• [10]Wilcox CE, Washburn R, Patel V: Seeking help for attention deficit hyperactivity disorder in developing countries: a study of parental explanatory models in Goa, India. Soc Sci Med 2007, 64:1600-1610.
• [11]Rutledge KJ, van den Bos W, McClure SM, Schweitzer JB: Training cognition in ADHD: current findings, borrowed concepts, and future directions. Neurotherapeutics 2012, 9:542-558.
• [12]Klingberg T: Training and plasticity of working memory. Trends Cogn Sci 2010, 14:317-324.
• [13]Tallal P, Miller SL, Bedi G, Byma G, Wang X, Nagarajan SS, Schreiner C, Jenkins WM, Merzenich MM: Language comprehension in language-learning impaired children improved with acoustically modified speech. Science 1996, 271:81-84.
• [14]Fisher M, Holland C, Merzenich MM, Vinogradov S: Using neuroplasticity-based auditory training to improve verbal memory in schizophrenia. Am J Psychiatry 2009, 166:805-811.
• [15]Smith GE, Housen P, Yaffe K, Ruff R, Kennison RF, Mahncke HW, Zelinski EM: A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study. J Am Geriatr Soc 2009, 57:594-603.
• [16]Anguera JA, Boccanfuso J, Rintoul JL, Al-Hashimi O, Faraji F, Janowich J, Kong E, Larraburo Y, Rolle C, Johnston E, Gazzaley A: Video game training enhances cognitive control in older adults. Nature 2013, 501:97-101.
• [17]Mishra J, Anguera J, Ziegler D, Gazzaley A: A Cognitive Framework for Understanding and Improving Interference Resolution in the Brain. In Chang Brains - Appl Brain Plast to Adv Recover Hum Abil. Edited by Merzenich M, Nahum M, van Vleet T. Elsevier; 2014. in press
• [18]Merzenich MM, DeCharms RC: Neural representations, experience, and change. In Mind–brain Contin Sens Process. Edited by Llinás RR, Churchland P. Cambridge, MA, US: The MIT Press; 1996:61-81.
• [19]Online Neuroplasticity Training for Remediation of ADHD in Adolescent Children (ONTRAC). ClinicalTrials.gov [http://clinicaltrials.gov/ct2/show/NCT01772485 webcite]
• [20]Patel V, Araya R, Chatterjee S, Chisholm D, Cohen A, de Silva M, Hosman C, McGuire H, Rojas G, van Ommeren M: Treatment and prevention of mental disorders in low-income and middle-income countries. Lancet 2007, 370:991-1005.