Collecting duct carcinoma of the kidney: a clinicopathological study of five cases

Diagnostic Pathology

Zhonghua Liu¹  Lei Shan¹  Degang Ding¹  Tianzhong Yan¹  Xiangsheng Zhang¹  Ruijin Zhou¹  Jianwei Hao¹  Xiangyang Wang¹ 

[1] Department of Urology, Henan Provincial People’s Hospital, Zhengzhou 450003, China

关键词: Pathology;    Diagnosis;    Collecting duct carcinoma;    Renal tumor;   

Others  :  806705
DOI  :  10.1186/1746-1596-8-96

 received in 2013-03-08, accepted in 2013-05-06,  发布年份 2013

【 摘 要 】

Objective

To investigate the clinicopathological features of collecting duct carcinoma (CDC) and improve its diagnosis and treatment.

Methods

A retrospective analysis was performed with clinical data including follow-up results of five patients with CDC.

Results

A total of 5 cases, including 4 males and 1 female, were included in this analysis with the average age 54 years (range 42 to 65). Patients mainly suffered from lumbar pain, hematuria, abdominal mass and low grade fever. Four patients underwent radical nephrectomy while another received palliative nephrectomy. Lymph node metastasis occurred in 3 cases and renal hilum fat metastasis happened to 2 other cases. Tumors was located in the renal medulla and presented invasive growth. They had a tubulopapillary architecture with the hobnail-shaped cells protruding into the glandular lumen, and were accompanied by interstitial fibrosis and dysplasia of epithelial cells in collecting ducts adjacent to the tumors. One tumor was staged at AJCC II, two at AJCC III and two at AJCC IV. Postoperative interferon immunotherapy was applied in 2 cases. Patients were followed up for 5 to 18 months and the average survival time was 10 months.

Conclusion

The CDC exhibits special clinicopathological features, high degree of malignancy and poor prognosis. The diagnosis depends on the histopathological examination. Early detection and early surgical treatment are still the main methods to improve the prognosis of patients with CDC.

Virtual Slides

The virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/3702794279387989 webcite

【 授权许可】

   
2013 Wang et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

Figure 4.

【 参考文献 】

• [1]Singh I, Nabi G: Bellini duct carcinoma: review of diagnosis and management. Int Urol Nephrol 2002, 1:91-95.
• [2]Verdorfer I, Culig Z, Hobisch A, Bartsch G, Hittmair A, Duba HC, Erdel M: Characterisation of a collecting duct carcinoma by cytogenetic analysis and comparative genomic hybridisation. Int J Oncol 1998, 13(3):461-464.
• [3]Davis CJ Jr, Mostofi FK, Sesterhenn IA: Renal medullary carcinoma. The seventh sickle cell nephropathy. Am J Surg Pathol 1995, 19:1-11.
• [4]Dimopoulos MA, Logothetis CJ, Markowitz A, Sella A, Amato R, Ro J: Collecting duct carcinoma of the kidney. Br J Urol 1993, 71:388-391.
• [5]Coogan CL, McKiel CF Jr, Flanagan MJ, Bormes TP, Matkov TG: Renal medullary carcinoma in patients with sickle cell trait. Urology 1998, 51:1049-1050.
• [6]Peyromaure M, Thiounn N, Scotte F, Vieillefond A, Debre B, Oudard S: Collecting duct carcinoma of the kidney: a clinicopathological study of 9 cases. J Urol 2003, 170:1138-1140.
• [7]Del Sordo R, Giansanti M, Bellezza G, Sidoni A: Thyroid transcription factor 1 expression in a case of renal collecting duct carcinoma. Hum Pathol 2012, 43:1153-1154. author reply 1154
• [8]Li B, Ding Q: A case report of collecting duct carcinoma of the kidney coexistent with giant adrenal myelolipoma. Can Urol Assoc J 2012, 6:E97-E100.
• [9]Yang GE, Seo JW, Park JH: Distal ureteral seeding metastasis of collecting duct carcinoma manifesting as deep vein thrombosis. Clin Radiol 2012, 67:936-939.
• [10]Lopez-Beltran A, Scarpelli M, Montironi R, Kirkali Z: WHO classification of the renal tumors of the adults. Eur Urol 2004, 2006(49):798-805.
• [11]Tokuda N, Naito S, Matsuzaki O, Nagashima Y, Ozono S, Igarashi T: Collecting duct (bellini duct) renal cell carcinoma: a nationwide survey in japan. J Urol 2006, 176:40-43. discussion 43
• [12]Orsola A, Trias I, Raventos CX, Espanol I, Cecchini L, Orsola I: Renal collecting (bellini) duct carcinoma displays similar characteristics to upper tract urothelial cell carcinoma. Urology 2005, 65:49-54.
• [13]Yoon SK, Nam KJ, Rha SH, Kim JK, Cho KS, Kim B, Kim KH, Kim KA: Collecting duct carcinoma of the kidney: CT and pathologic correlation. Eur J Radiol 2006, 57:453-460.
• [14]Bansal P, Kumar S, Mittal N, Kundu AK: Collecting duct carcinoma: a rare renal tumor. Saudi J Kidney Dis Transpl 2012, 23:810-812.
• [15]Kim JK, Kim TK, Ahn HJ, Kim CS, Kim KR, Cho KS: Differentiation of subtypes of renal cell carcinoma on helical CT scans. Am J Roentgenol 2002, 178:1499-1506.
• [16]Chao D, Zisman A, Pantuck AJ, Gitlitz BJ, Freedland SJ, Said JW, Figlin RA, Belldegrun AS: Collecting duct renal cell carcinoma: clinical study of a rare tumor. J Urol 2002, 167:71-74.
• [17]Husillos A, Herranz-Amo F, Subira D, Lledo E, Molina-Escudero R, Hernandez-Fernandez C: Collecting duct renal cell carcinoma. Actas Urol Esp 2011, 35:368-371.
• [18]Gabriela Q-G, Sergio P-O, Karime C-O, Richard G, Schwartz MR, Ayala AG, Monzon FA: Synchronous clear cell renal cell carcinoma and tubulocystic carcinoma: genetic evidence of independent ontogenesis and implications of chromosomal imbalances in tumor progression. Diagn Pathol 2012, 7:21. BioMed Central Full Text
• [19]Tsan-Yu H, Yi-Che CC, Wen-Hsiang C, Siu-Chung C, Liang-Che C, Cheng-Cheng H, Hui-Ping C, Jim-Ray C: De novo malignant solitary fibrous tumor of the kidney. Diagn Pathol 2011, 6:96. BioMed Central Full Text
• [20]Ling Z, Jie L, Honglei Z, Jiping D: Pigmented paraganglioma of the kidney: a case report. Diagn Pathol 2012, 7:77. BioMed Central Full Text
• [21]Qingfu Z, Jian M, Siyang Z, Xueshan Q: Primary micro neuroendocrine tumor arising in a horseshoe kidney with cyst: report of a case and review of literature. Diagn Pathol 2012, 7:126. BioMed Central Full Text
• [22]Carl Ludwig B, Bernhard H, Arne S, Heinz-Joachim R, Felix B: N-cadherin is differentially expressed in histological subtypes of papillary renal cell carcinoma. Diagn Pathol 2012, 7:95. BioMed Central Full Text
• [23]Leos K, Ivo V, Jan D, Ivo C, Dalibor P, Alexandr P, Radek L, Martina R, Pavel F, Zdenka K, Ondrej S: HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma. Diagn Pathol 2012, 7:58. BioMed Central Full Text
• [24]Li M, Vuolo MA, Weidenheim KM, Minsky LS: Collecting-duct carcinoma of the kidney with prominent signet ring cell features. Mod Pathol 2001, 14:623-628.
• [25]Miyake H, Haraguchi T, Takenaka A, Fujisawa M: Metastatic collecting duct carcinoma of the kidney responded to sunitinib. Int J Clin Oncol 2011, 16:153-155.
• [26]el Tazi M, Essadi I, Tazi MF, Ahellal Y, M’Rabti H, Errihani H: Retraction: metastatic collecting duct carcinoma of the kidney treated with sunitinib. World J Surg Oncol 2011, 9:136. BioMed Central Full Text
• [27]el Tazi M, Essadi I, Tazi MF, Ahellal Y, M’Rabti H, Errihani H: Metastatic collecting duct carcinoma of the kidney treated with sunitinib. World J Surg Oncol 2011, 9:73. BioMed Central Full Text