A peripheral giant cell granuloma with extensive osseous metaplasia or a hybrid peripheral giant cell granuloma-peripheral ossifying fibroma: a case report

Journal of Medical Case Reports

Kalu UE Ogbureke²  Cleverick D Johnson¹  Gary Frey¹  Matthew Seals¹  Nadarajah Vigneswaran²  Ezinne I Ogbureke¹ 

[1] Department of General Practice and Dental Public Health, The University of Texas School of Dentistry, Houston, TX, USA;Department of Diagnostics and Biomedical Sciences, The University of Texas School of Dentistry, Houston, TX, USA

关键词: Peripheral ossifying fibroma;    Peripheral giant cell granuloma with osseous metaplasia;    Peripheral giant cell granuloma;    Dental implants;    Collision/hybrid lesion;   

Others  :  1145562
DOI  :  10.1186/1752-1947-9-14

 received in 2014-10-23, accepted in 2014-12-08,  发布年份 2015

【 摘 要 】

Introduction

Peripheral giant cell granuloma and peripheral ossifying fibroma are clinicopathologically distinct gingival lesions. Both are included in clinical differential diagnoses of common benign and reactive gingival epulides in humans. It is often impossible to make a clinical distinction between the two entities, thereby making definitive diagnosis dependent on histopathologic features. While our search of the English literature revealed several reports of peripheral giant cell granuloma with ‘bone formation’, we were unable to identify any reports of hybrid peripheral ossifying fibroma-peripheral giant cell granulomas.

Case presentation

We report a case of a 44-year-old Caucasian man presenting with a three-month history of swelling of his right posterior mandible, related to an area of previous dental implant restoration. A clinical examination revealed modest extraoral facial swelling of his right posterior mandible, while an intraoral examination showed a 45×25×15mm sessile, lobular soft tissue mass of the right posterior mandibular gingiva. The mucosal covering of the lesion exhibited focal surface ulceration. A panoramic radiograph showed two implants at the vicinity of the lesion with no other significant findings. An excisional biopsy of the lesion followed by histopathologic examination of the biopsy specimen revealed salient and distinctive features of peripheral giant cell granuloma and of peripheral ossifying fibroma, estimated at near equal proportions. This raises the possibility of a hybrid odontogenic lesion.

Conclusion

The presentation of this lesion, with areas of peripheral giant cell granuloma along with a distinct area of extensive osseous formation and stroma reminiscent of a peripheral ossifying fibroma, justifies consideration of this as a possible hybrid lesion. Although the biologic behavior of a combined lesion is not anticipated to deviate significantly from that of either of the single entities, this case resurrects an enduring debate as to whether peripheral giant cell granuloma and peripheral ossifying fibroma are simply parts of a disease spectrum, or whether some of these lesions represent true hybrid lesions. It is therefore recommended that more cases with histopathologic features similar to the lesion in our case be reported in the literature to further elucidate the histogenesis of these lesions.

【 授权许可】

   
2015 Ogbureke et al.; licensee BioMed Central.

【 图 表 】

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