Breast vibro-acoustography: initial results show promise

Breast Cancer Research

Mostafa Fatemi²  James F Greenleaf²  Randall R Kinnick²  Rickey E Carter⁴  Matthew W Urban²  Dana H Whaley³  Azra Alizad¹ 

[1] Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA;Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA;Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA;Division of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA

关键词: vibro-acoustography;    ultrasound;    radiation force breast imaging;    breast lesions;    acoustic imaging;   

Others  :  795689
DOI  :  10.1186/bcr3323

 received in 2012-06-16, accepted in 2012-09-29,  发布年份 2012

【 摘 要 】

Introduction

Vibro-acoustography (VA) is a recently developed imaging modality that is sensitive to the dynamic characteristics of tissue. It detects low-frequency harmonic vibrations in tissue that are induced by the radiation force of ultrasound. Here, we have investigated applications of VA for in vivo breast imaging.

Methods

A recently developed combined mammography-VA system for in vivo breast imaging was tested on female volunteers, aged 25 years or older, with suspected breast lesions on their clinical examination. After mammography, a set of VA scans was acquired by the experimental device. In a masked assessment, VA images were evaluated independently by 3 reviewers who identified mass lesions and calcifications. The diagnostic accuracy of this imaging method was determined by comparing the reviewers' responses with clinical data.

Results

We collected images from 57 participants: 7 were used for training and 48 for evaluation of diagnostic accuracy (images from 2 participants were excluded because of unexpected imaging artifacts). In total, 16 malignant and 32 benign lesions were examined. Specificity for diagnostic accuracy was 94% or higher for all 3 reviewers, but sensitivity varied (69% to 100%). All reviewers were able to detect 97% of masses, but sensitivity for detection of calcification was lower (≤ 72% for all reviewers).

Conclusions

VA can be used to detect various breast abnormalities, including calcifications and benign and malignant masses, with relatively high specificity. VA technology may lead to a new clinical tool for breast imaging applications.

【 授权许可】

   
2012 Alizad et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 2.

Figure 3.

Figure 4.

Figure 5.

Figure 6.

Figure 7.

Figure 8.

【 参考文献 】

• [1]Warner E: Breast-cancer screening. New Engl J Med 2011, 365:1025-1032.
• [2]Corsetti V, Houssami N, Ghirardi M, Ferrari A, Speziani M, Bellarosa S, Remida G, Gasparotti C, Galligioni E, Ciatto S: Evidence of the effect of adjunct ultrasound screening in women with mammography-negative dense breasts: Interval breast cancers at 1 year follow-up. Eur J Cancer 2011, 47:1021-1026.
• [3]Gordon PB, Goldenberg SL: Malignant breast masses detected only by ultrasound. A retrospective review. Cancer 1995, 76:626-630.
• [4]Kolb TM, Lichy J, Newhouse JH: Comparison of the performance of screening mammography, physical examination, and breast US and evaluation of factors that influence them: an analysis of 27,825 patient evaluations. Radiology 2002, 225:165-175.
• [5]Berg WA, Zhang Z, Lehrer D, Jong RA, Pisano ED, Barr RG, Böhm-Vélez M, Mahoney MC, Evans WP III, Larsen LH: Detection of breast cancer with addition of annual screening ultrasound or a single screening MRI to mammography in women with elevated breast cancer risk. JAMA 2012, 307:1394-1404.
• [6]Berg WA, Blume JD, Cormack JB, Mendelson EB, Lehrer D, Böhm-Vélez M, Pisano ED, Jong RA, Evans WP, Morton MJ: Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer. JAMA: 2008, 299:2151-2163.
• [7]Teh W, Wilson A: The role of ultrasound in breast cancer screening. A consensus statement by the European Group for Breast Cancer Screening. Eur J Cancer 1998, 34:449-450.
• [8]Moon WK, Myung JS, Lee YJ, Park IA, Noh DY, Im JG: US of ductal carcinoma in situ. Radiographics 2002, 22:269-280. discussion 280-261
• [9]Orel SG: MR imaging of the breast. Radiol Clin North Am 2000, 38:899-913.
• [10]Heywang-Köbrunner S, Bick U, Bradley W Jr, Boné B, Casselman J, Coulthard A, Fischer U, Müller-Schimpfle M, Oellinger H, Patt R, Teubner J, Friedrich M, Newstead G, Holland R, Schauer A, Sickles EA, Tabar L, Waisman J, Wernecke KD: International investigation of breast MRI: results of a multicentre study (11 sites) concerning diagnostic parameters for contrast-enhanced MRI based on 519 histopathologically correlated lesions. Eur radiol 2001, 11:531-546.
• [11]Sarvazyan A: Elastic properties of soft tissue. Handbook of elastic properties of solids, liquids and gases 2001, 3:107-127.
• [12]Krouskop TA, Wheeler TM, Kallel F, Garra BS, Hall T: Elastic moduli of breast and prostate tissues under compression. Ultrason imaging 1998, 20:260.
• [13]Sarvazyan A, Hall TJ, Urban MW, Fatemi M, Aglyamov SR, Garra BS: An overview of elastography - an emerging branch of medical imaging. Curr Med Imaging Rev 2011, 7:255-282.
• [14]McKnight AL, Kugel JL, Rossman PJ, Manduca A, Hartmann LC, Ehman RL: MR elastography of breast cancer: preliminary results. Am J Rroentgenol 2002, 178:1411-1417.
• [15]Lorenzen J, Sinkus R, Lorenzen M, Dargatz M, Leussler C, Roschmann P, Adam G: MR elastography of the breast:preliminary clinical results. Rofo 2002, 174:830-834.
• [16]Hiltawsky KM, Krüger M, Starke C, Heuser L, Ermert H, Jensen A: Freehand ultrasound elastography of breast lesions: clinical results. Ultrasound Med Biol 2001, 27:1461-1469.
• [17]Garra BS, Cespedes EI, Ophir J, Spratt SR, Zuurbier RA, Magnant CM, Pennanen MF: Elastography of breast lesions: initial clinical results. Radiology 1997, 202:79-86.
• [18]Ginat DT, Destounis SV, Barr RG, Castaneda B, Strang JG, Rubens DJ: US Elastography of breast and prostate lesions. Radiographics 2009, 29:2007-2016.
• [19]Schaefer F, Heer I, Schaefer P, Mundhenke C, Osterholz S, Order B, Hofheinz N, Hedderich J, Heller M, Jonat W: Breast ultrasound elastography-results of 193 breast lesions in a prospective study with histopathologic correlation. Eur J Radiol 2011, 77:450-456.
• [20]Trahey GE, Palmeri ML, Bentley RC, Nightingale KR: Acoustic radiation force impulse imaging of the mechanical properties of arteries: In vivo and ex vivo results. Ultrasound Med Biol 2004, 30:1163-1171.
• [21]Tanter M, Bercoff J, Athanasiou A, Deffieux T, Gennisson JL, Montaldo G, Muller M, Tardivon A, Fink M: Quantitative assessment of breast lesion viscoelasticity: initial clinical results using supersonic shear imaging. Ultrasound Med Biol 2008, 34:1373-1386.
• [22]Fatemi M, Greenleaf JF: Ultrasound-stimulated vibro-acoustic spectrography. Science 1998, 280:82-85.
• [23]Fatemi M, Greenleaf JF: Vibro-acoustography: an imaging modality based on ultrasound-stimulated acoustic emission. Proc Natl Acad Sci USA 1999, 96:6603.
• [24]Fatemi M, Greenleaf JF: Probing the dynamics of tissue at low frequencies with the radiation force of ultrasound. Phys Med Biol 2000, 45:1449.
• [25]Fatemi M, Manduca A, Greenleaf JF: Imaging elastic properties of biological tissues by low-frequency harmonic vibration. Proceedings of the IEEE 2003, 91:1503-1519.
• [26]Fatemi M, Greenleaf J: Imaging and evaluating the elastic properties of biological tissues. BMUS BULLETIN 2000, 8:16-18.
• [27]Urban M, Alizad A, Aquino W, Greenleaf JF, Fatemi M: A review of vibro-acoustography and its applications in medicine. Curr Med Imaging Rev 2011, 7:350-359.
• [28]Fatemi M, Wold LE, Alizad A, Greenleaf JF: Vibro-acoustic tissue mammography. IEEE Trans Med Imaging 2002, 21:1-8.
• [29]Alizad A, Fatemi M, Wold LE, Greenleaf JF: Performance of vibro-acoustography in detecting microcalcifications in excised human breast tissue: A study of 74 tissue samples. IEEE Trans Med Imaging 2004, 23:307-312.
• [30]Alizad A, Wold LE, Greenleaf JF, Fatemi M: Imaging mass lesions by vibro-acoustography: modeling and experiments. IEEE Trans Med Imaging 2004, 23:1087-1093.
• [31]Alizad A, Fatemi M, Whaley DH, Greenleaf JF: Application of vibro-acoustography for detection of calcified arteries in breast tissue. J Ultrasound Med 2004, 23:267-273.
• [32]Wilson EB: Probable inference, the law of succession, and statistical inference. Journal of the American Statistical Association 1927, 22:209-212.
• [33]Sehgal CM, Weinstein SP, Arger PH, Conant EF: A review of breast ultrasound. J Mammary Gland Biol Neoplasia 2006, 11:113-123.
• [34]Kamimura H, Urban M, Carneiro A, Fatemi M, Alizad A: Vibro-acoustography beam formation with reconfigurable arrays. IEEE Trans Ultrason Ferroelectr Freq Control 2012, 59:1421-1431.
• [35]Urban MW, Chalek C, Kinnick RR, Kinter TM, Haider B, Greenleaf JF, Thomenius KE, Fatemi M: Implementation of vibro-acoustography on a clinical ultrasound system. IEEE Trans Ultrason Ferroelectr Freq Control 2011, 58:1169-1181.