The effect of a biphasic injectable bone substitute on the interface strength in a rabbit knee prosthesis model

Journal of Orthopaedic Surgery and Research

Jian-Sheng Wang¹  Isam Atroshi²  Hanna Isaksson³  Lars Lidgren¹  Magnus Tägil¹  Vasilis Zampelis² 

[1] Department of Orthopedics, Clinical Sciences, Lund University, Lund SE-221 85, Sweden;Department of Orthopedics, Hässleholm Hospital, Hässleholm SE-281 25, Sweden;Department of Applied Physics, University of Eastern Finland, Kuopio FI-70211, Finland

关键词: Histomorphometry;    Interface strength;    Calcium sulfate;    Hydroxyapatite;    Injectable bone substitute;   

Others  :  817673
DOI  :  10.1186/1749-799X-8-25

 received in 2013-02-27, accepted in 2013-07-25,  发布年份 2013

【 摘 要 】

Background

In joint prosthetic surgery, various methods are used to provide implant stability. We used an injectable bone substitute, composed of calcium sulfate/hydroxyapatite, as bone defect filler to stabilize a tibia prosthesis in an experimental rabbit model. The aim of the study was to investigate and compare the stability of prosthetic fixation with and without the use of an injectable bone substitute.

Methods

Sixteen rabbits were used and the tibia prostheses were implanted bilaterally, one side with the prosthesis alone and the other side with the prosthesis and calcium sulfate/hydroxyapatite (Cerament™). The rabbits were randomly divided into two groups and euthanized after 6 and 12 weeks, respectively. The prosthesis was extracted measuring the pull-out force in an Instron tester, and the bone surrounding the former prosthesis site was analyzed by histology, histomorphometry, and micro-computed tomography.

Results

At 6 weeks no difference in maximum pull-out force was found between the prostheses fixed with or without Cerament™. At 12 weeks the maximum pull-out force for the prostheses with Cerament™ was significantly higher than that for the prostheses without Cerament™ (p = 0.04). The maximum pull-out force at 12 weeks was significantly higher than that at 6 weeks for the prostheses fixed with Cerament™ (p = 0.03) but not for the prostheses without.

Conclusion

We conclude that early prosthesis-bone interface strength is not influenced by a bone substitute. However, during remodeling, the bone substitute might provide improved mechanical support for the prosthesis. The results support further studies of the use of injectable calcium sulfate/hydroxyapatite in fixation of prosthetic joint implants.

【 授权许可】

   
2013 Zampelis et al.; licensee BioMed Central Ltd.

【 图 表 】

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