Human papillomavirus type 16 E6 variants in France and risk of viral persistence

Infectious Agents and Cancer

Christine Clavel²  Massimo Tommasino¹  Silvia Franceschi¹  Véronique Dalstein²  Jean-Damien Combes¹  Gary M Clifford¹  Tarik Gheit¹  Iris Cornet¹ 

[1] International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, 69372 Cedex 08, France;INSERM UMR-S 903 / Université de Reims Champagne-Ardenne / CHU Reims, Laboratoire Pol-Bouin, Reims, France

关键词: Persistence;    Variants;    HPV;    Polymorphism;    Cohort;    Cervical cancer screening;   

Others  :  803211
DOI  :  10.1186/1750-9378-8-4

 received in 2012-10-18, accepted in 2012-12-17,  发布年份 2013

【 摘 要 】

Background

Only a small portion of HPV 16 infections persist and can lead to cervical intraepithelial lesions and cancer. Factors that favour HPV persistence versus clearance are still poorly understood, but several studies have suggested that HPV intra-type variants may influence persistence and clinical outcome. The aim of this study was to assess the possible association between HPV 16 variants and the risk for viral persistence in the general population of France.

Methods

One hundred and forty two women infected with HPV 16 with normal cytology, without previous treatment for cervical lesions, and with a valid second follow-up visit 4 to 16 months later, were selected from patients participating in routine cervical cancer screening in the Reims HPV Primary Screening Cohort Study. HPV intra-type variants were determined by sequencing the HPV 16 E6 open reading frame, and were compared for viral persistence at the second visit using odds ratios (OR) to estimate relative risk.

Results

Although no statistically significant differences in risk for persistence were observed by the HPV 16 variant lineage, European variants containing the polymorphism 350 T (EUR-350 T) appeared to persist more often than those containing 350 G (EUR-350 G) (OR = 1.6, 95% CI = 0.8-3.4).

Conclusions

No strong differences were observed in the risk of viral persistence for the HPV 16 variants that predominate in France.

【 授权许可】

   
2013 Cornet et al.; licensee BioMed Central Ltd.

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