Infectious Agents and Cancer | |
Human papillomavirus type 16 E6 variants in France and risk of viral persistence | |
Christine Clavel2  Massimo Tommasino1  Silvia Franceschi1  Véronique Dalstein2  Jean-Damien Combes1  Gary M Clifford1  Tarik Gheit1  Iris Cornet1  | |
[1] International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, 69372 Cedex 08, France;INSERM UMR-S 903 / Université de Reims Champagne-Ardenne / CHU Reims, Laboratoire Pol-Bouin, Reims, France | |
关键词: Persistence; Variants; HPV; Polymorphism; Cohort; Cervical cancer screening; | |
Others : 803211 DOI : 10.1186/1750-9378-8-4 |
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received in 2012-10-18, accepted in 2012-12-17, 发布年份 2013 | |
【 摘 要 】
Background
Only a small portion of HPV 16 infections persist and can lead to cervical intraepithelial lesions and cancer. Factors that favour HPV persistence versus clearance are still poorly understood, but several studies have suggested that HPV intra-type variants may influence persistence and clinical outcome. The aim of this study was to assess the possible association between HPV 16 variants and the risk for viral persistence in the general population of France.
Methods
One hundred and forty two women infected with HPV 16 with normal cytology, without previous treatment for cervical lesions, and with a valid second follow-up visit 4 to 16 months later, were selected from patients participating in routine cervical cancer screening in the Reims HPV Primary Screening Cohort Study. HPV intra-type variants were determined by sequencing the HPV 16 E6 open reading frame, and were compared for viral persistence at the second visit using odds ratios (OR) to estimate relative risk.
Results
Although no statistically significant differences in risk for persistence were observed by the HPV 16 variant lineage, European variants containing the polymorphism 350 T (EUR-350 T) appeared to persist more often than those containing 350 G (EUR-350 G) (OR = 1.6, 95% CI = 0.8-3.4).
Conclusions
No strong differences were observed in the risk of viral persistence for the HPV 16 variants that predominate in France.
【 授权许可】
2013 Cornet et al.; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
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20140708035248172.pdf | 161KB | download |
【 参考文献 】
- [1]zur Hausen H: Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2002, 2(5):342-350.
- [2]Maucort-Boulch D, Plummer M, Castle PE, Demuth F, Safaeian M, Wheeler CM, Schiffman M: Predictors of human papillomavirus persistence among women with equivocal or mildly abnormal cytology. Int J Cancer 2010, 126(3):684-691.
- [3]Gheit T, Cornet I, Clifford GM, Iftner T, Munk C, Tommasino M, Kjaer SK: Risks for persistence and progression by human papillomavirus type 16 variant lineages among a population-based sample of Danish women. Cancer Epidemiol Biomarkers Prev 2011, 20(7):1315-1321.
- [4]Schiffman M, Rodriguez AC, Chen Z, et al.: A population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasia. Cancer Res 2010, 70(8):3159-3169.
- [5]Zuna RE, Moore WE, Shanesmith RP, Dunn ST, Wang SS, Schiffman M, Blakey GL, Teel T: Association of HPV16 E6 variants with diagnostic severity in cervical cytology samples of 354 women in a US population. Int J Cancer 2009, 25(11):2609-2613.
- [6]Sathish N, Abraham P, Peedicayil A, Sridharan G, Chandy G: HPV 16 E6 sequence variations in Indian patients with cervical neoplasia. Cancer Lett 2005, 229(1):93-99.
- [7]Villa LL, Sichero L, Rahal P, Caballero O, Ferenczy A, Rohan T, Franco EL: Molecular variants of human papillomavirus types 16 and 18 preferentially associated with cervical neoplasia. J Gen Virol 2000, 81(Pt 12):2959-2968.
- [8]Berumen J, Ordonez RM, Lazcano E, et al.: Asian-American variants of human papillomavirus 16 and risk for cervical cancer: a case–control study. J Natl Cancer Inst 2001, 93(17):1325-1330.
- [9]Burk RD, Chen Z, Harari A, Smith BC, Kocjan BJ, Maver PJ, Poljak M: Classification and nomenclature system for human alphapapillomavirus variants: general features, nucleotide landmarks and assignment of hpv6 and hpv11 isolates to variant lineages. Acta Dermatovenerol Alp Panonica Adriat 2011, 20(3):113-123.
- [10]Chen Z, Terai M, Fu L, Herrero R, Desalle R, Burk RD: Diversifying selection in human papillomavirus type 16 lineages based on complete genome analyses. J Virol 2005, 79(11):7014-7023.
- [11]Chen Z, Schiffman M, Herrero R, et al.: Evolution and taxonomic classification of Human Papillomavirus 16 (HPV16)-related variant genomes: HPV31, HPV33, HPV35, HPV52, HPV58 and HPV67. PLoS One 2011, 6(5):e20183.
- [12]Yamada T, Manos MM, Peto J, Greer CE, Munoz N, Bosch FX, Wheeler CM: Human papillomavirus type 16 sequence variation in cervical cancers: a worldwide perspective. J Virol 1997, 71(3):2463-2472.
- [13]Zehbe I, Tachezy R, Mytilineos J, et al.: Human papillomavirus 16 e6 polymorphisms in cervical lesions from different European populations and their correlation with human leukocyte antigen class ii haplotypes. Int J Cancer 2001, 94(5):711-716.
- [14]Grodzki M, Besson G, Clavel C, Arslan A, Franceschi S, Birembaut P, Tommasino M, Zehbe I: Increased risk for cervical disease progression of French women infected with the human papillomavirus type 16 e6-350 g variant. Cancer Epidemiol Biomarkers Prev 2006, 15(4):820-822.
- [15]Xi LF, Koutsky LA, Hildesheim A, Galloway DA, Wheeler CM, Winer RL, Ho J, Kiviat NB: Risk for high-grade cervical intraepithelial neoplasia associated with variants of human papillomavirus types 16 and 18. Cancer Epidemiol Biomarkers Prev 2007, 16(1):4-10.
- [16]Clavel C, Masure M, Bory JP, et al.: Human papillomavirus testing in primary screening for the detection of high-grade cervical lesions: a study of 7932 women. Br J Cancer 2001, 84(12):1616-1623.
- [17]Clavel C, Cucherousset J, Lorenzato M, et al.: Negative human papillomavirus testing in normal smears selects a population at low risk for developing high-grade cervical lesions. Br J Cancer 2004, 90(9):1803-1808.
- [18]Myers G, Delius H, Icenogle J, Bernard HU, Baker C, Halpern A, Wheeler C: Human Papillomaviruses 1995: A compilation and analysis of nucleic acid and amino acid sequences. Los Alamos, NM: Los Alamos National Library; 1995.