Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases

Immunity & Ageing

Vittorio Calabrese⁵  Edward J. Calabrese³  Agostino Serra⁴  Luigi Maiolino⁴  Antonino Petralia⁶  Cateno Concetto Petralia¹  Maria Laura Ontario⁵  Paola Di Mauro⁴  Guido Koverech⁵  Cesare Mancuso²  Sandro Dattilo⁵ 

[1] University College London Hospitals, NHS Foundation Trust, London, UK;Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy;Environmental Health Sciences Division, School of Public Health, University of Massachusetts, Amherst, MA, USA;Department of Medical and Surgery Specialties, University of Catania, Catania, Italy;Department of Biomedical and Biotechnological Sciences, University of Catania, Via Andrea Doria, Catania, 95100, Italy;Department of Clinical and Experimental Medicine, School of Medicine, University of Catania, Catania, Italy

关键词: Vitagenes;    Neurodegenerative disorders;    Bilirubin;    Oxidative stress;    Heme oxygenase;    Heat shock proteins;    Alzheimer’s disease;   

Others  :  1230783
DOI  :  10.1186/s12979-015-0046-8

 received in 2015-08-01, accepted in 2015-10-15,  发布年份 2015

【 摘 要 】

Modulation of endogenous cellular defense mechanisms via the vitagene system represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneration. The possibility of high-throughoutput screening using proteomic techniques, particularly redox proteomics, provide more comprehensive overview of the interaction of proteins, as well as the interplay among processes involved in neuroprotection. Here by introducing the hormetic dose response concept, the mechanistic foundations and applications to the field of neuroprotection, we discuss the emerging role of heat shock protein as prominent member of vitagene network in neuroprotection and redox proteomics as a tool for investigating redox modulation of stress responsive vitagenes. Hormetic mechanisms are reviewed as possibility of targeted therapeutic manipulation in a cell-, tissue- and/or pathway-specific manner at appropriate points in the neurodegenerative disease process.

【 授权许可】

   
2015 Dattilo et al.

【 图 表 】

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