CO2 laser versus cold steel margin analysis following endoscopic excision of glottic cancer

Journal of Otolaryngology-Head & Neck Surgery

S Mark Taylor²  Michael L Hinni³  Jonathan Trites⁴  Robert D Hart⁴  Timothy Brown⁴  Martin Bullock¹  Matthew H Rigby⁴  Fawaz M Makki⁴ 

[1] Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada;Suite 3052, Dickson Bldg., 5820 University Avenue, Halifax, NS B3H 1 V9, Canada;Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Phoenix, AZ, USA;Department of Surgery, Division of Otolaryngology Head & Neck Surgery, Dalhousie University, Halifax, Nova Scotia, Canada

关键词: Tumor margin;    CO₂ Laser surgery;    Glottic cancer;   

Others  :  1144006
DOI  :  10.1186/1916-0216-43-6

 received in 2013-04-03, accepted in 2014-01-27,  发布年份 2014

【 摘 要 】

Objective

To compare the suitability of CO₂ laser with steel instruments for margin excision in transoral laser microsurgery.

Methods

Prospective randomized blinded study. Patients with glottic cancer undergoing laser resection were randomized to margin excision by either steel instruments or CO₂ laser. Margins were analyzed for size, interpretability and degree of artifact by a pathologist who was blinded to technique.

Results

45 patients were enrolled in the study with 226 total margins taken. 39 margins taken by laser had marked artifact and 0 were uninterpretable. 20 margins taken by steel instruments had marked artifact, and 2 were uninterpretable. Controlling for margin size, the laser technique was associated with increasing degrees of margin artifact (p = 0.210), but there was no difference in crude rates of uninterpretability (p = 0.24).

Conclusion

Laser margin excision is associated with a greater degree of artifact than steel instrument excision, but was not associated with higher rate of uninterpretability.

【 授权许可】

   
2014 Makki et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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