Idiopathic pulmonary hemosiderosis - a diagnostic challenge

Italian Journal of Pediatrics

Sashenka Sallabanda²  Robert Lluka²  Elmira Kola²  Ermela Celaj²  Durim Sala²  Luljeta Kota¹  Ilirjana Bakalli² 

[1] Paediatric Pneumology, University Hospital Center “Mother Theresa”, Tirana, Albania;PICU, University Hospital Center “Mother Theresa”, Tirana, Albania

关键词: Children;    Anemia;    Pulmonary hemosiderosis;   

Others  :  802519
DOI  :  10.1186/1824-7288-40-35

 received in 2014-01-29, accepted in 2014-03-28,  发布年份 2014

【 摘 要 】

Idiopathic pulmonary hemosiderosis is a rare disorder that can occur at any age and is characterized by the triad of hemoptysis, iron deficiency anemia and diffuse pulmonary infiltrates. The clinical course is exceedingly variable especially in children and a substantial proportion of this age group is undiagnosed. It is probably due to the fact that iron deficiency anemia may be the first and the only manifestation of IPH, preceding other symptoms and signs by several months and IPH is not considered as a rare cause of anemia, unless the typical triad is present. We present a case of IPH in a 13-year-old girl, treated for several months with persistent iron deficiency anemia, without response to therapy.

【 授权许可】

   
2014 Bakalli et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]Taytard J, Nathan N, Blic J, Fayon M, Epaud R, Deschildre A, Troussier F, Lubrano M, Chiron R, Reix P, Cros P, Mahloul M, Michon D, Clement A, Corvol A: New insights into pediatric idiopathic pulmonary hemosiderosis: the French RespiRare® cohort. Orphanet J Rare Dis 2013, 8:161. BioMed Central Full Text
• [2]Kliegman RM, Behrman RE, Jenson HB, Stanton BF: Nelson Textbook of Pediatrics. 18th edition. USA: Saunders (Elsevier Science); 2007:1824-1830.
• [3]Kamienska E, Urasinski T, Gawlikowska-Sroka A, Glura B, Pogorzelski B: Idiopathic pulmonary hemosiderosis in a 9-year-old girl. Eur J Med Res 2009, 14(Suppl 4):112-115.
• [4]Chen K, Hsiao CC, Huang SC, Ko SF, Niu CK: Anemia as the sole presenting symptom of idiopathic pulmonary hemosiderosis: report of two cases. Chang Gung Med J 2004, 27:824-829.
• [5]Datta AK, Ghosh T, Ghosh MK, Nayak K, Das SK: Pediatric oncall. 2009., 6(3) Available at: [http://www.pediatriconcall.com/Journal/Article/FullText.aspx?artid=63&type=J&tid=&imgid=&reportid=117&tbltype= webcite]
• [6]Khonglah Y, Raphael V, Bhuyan A, Gogoi P, Dass R: Idiopathic pulmonary haemosiderosis: diagnosis by gastric lavage. African Journal of Respiratory Medicine 2013, 8(2):26-27.
• [7]Napchan GD, Bye MR: Hemosiderosis. Last Updated: Apr 16, 2012. Available at: [http://emedicine.medscape.com/article/1002002-overview webcite]
• [8]Ioachimescu OC, Sieber S, Kotch A: Idiopathic pulmonary haemosiderosis revisited. Eur Respir J 2004, 24:162-170.
• [9]Yao TC, Hung IJ, Wong KS, Huang JL, Niu CK: Pitfalls in the diagnosis of idiopathic pulmonary haemosiderosis. Arch Dis Child 2002, 86:436-438.
• [10]Bulucea C, Sorin D: Idiopathic pulmonary hemosiderosis in children: a Romanian experience. Pediatrics 2008, 121 Suppl:158-159.
• [11]Idiopathic Pulmonary Haemosiderosis Last updated: 15 March 2013. Available at: [http://en.wikipedia.org/wiki/Idiopathic_pulmonary_haemosiderosis webcite]
• [12]Willms H, Gutjahr K, Juergens UR, Hammerschmidt S, Gessner C, Hoheisel G, Wirtz H, Gillissen A: Diagnostics and therapy of idiopathic pulmonary hemosiderosis. Med Klin (Munich) 2007, 102(6):445-450.
• [13]Poggi V, Vecchio A, Menna F, Menna G: Idiopathic pulmonary hemosiderosis: a rare cause of iron –deficiency anemia in childhood. J Pediatr Hematol Oncol 2011, 33(4):160-162.
• [14]Ferrari GF, Fioretto JR, Adriano FR, Alves AF, Gicélia S, Brandão GS: Idiopathic pulmonary hemosiderosis: case report. J Pediatr (Rio J) 2000, 76(2):149-152.
• [15]Sankararaman S, Shah K, Maddox K, Velayuthan S, Scott LK: Clinical case of the month. Idiopathic pulmonary hemosiderosis presenting as a rare cause of iron deficiency anemia in a toddler--a diagnostic challenge. J La State Med Soc 2012, 164(5):293-296.
• [16]Idiopathic pulmonary hemosiderosis Last updated: 1/29/2013. Available at: [http://rarediseases.info.nih.gov/gard/6763/idiopathic-pulmonary-hemosiderosis/resources/1 webcite]
• [17]Erdağ GC, Vitrinel A, Mutlu GY, Akin Y, Sadikoğlu S, Kartal LK: Idiopathic pulmonary hemosiderosis- a case report. Marmara Medical Journal 2006, 19(1):33-35.
• [18]Rathi PS, Chetan G, Aggarwal R, Kini U, Rao B: Primary pulmonary hemosiderosis-a rare cause of microcytic hypochromic anemia. Curr Pediatr Res 2011, 15(1):1-3.
• [19]Afzal N, Mushtaq A, Rahman A, Qureshi S: Idiopathic pulmonary haemosiderosis presenting as severe iron deficiency anaemia–a case from Pakistan. J Pak Med Assoc 2012, 62(8):845-847.
• [20]Vishal G, Dalal E, Raval N: Idiopathic pulmonary haemosiderosis. Natl J Med Res 2013, 3(3):292-293.
• [21]Gilman PA, Zinkham WH: Severe idiopathic pulmonary hemosiderosis in the absence of clinical or radiologic evidence of pulmonary disease. J Pediatr 1969, 75(1):118-121.
• [22]Kiper N, Göçmen A, Ozçelik U, Dilber E, Anadol D: Long-term clinical course of patients with idiopathic pulmonary hemosiderosis (1979–1994): prolonged survival with low-dose corticosteroid therapy. Pediatr Pulmonol 1999, 27(3):180-184.
• [23]Keller C, Langston C: Childhood idiopathic pulmonary hemosiderosis. N Engl J Med 2000, 343:781.
• [24]Shah GS, Parakh P, Chalise S, Mehta K, Mishra OP: Idiopathic pulmonary hemosiderosis: a case report with review of related literature. J Clin Case Rep 2012, 2:12.
• [25]Kabra SK, Bhargava S, Lodha R, Satyavani A, Walia M: Idiopathic pulmonary hemosiderosis: clinical profile and follow up of 26 children. Indian Pediatr 2007, 44(5):333-338.
• [26]Habermann TM, Ghosh AK: Mayo Clinic Internal Medicine: Concise Textbook. 1st edition. Rochester, Minnesota, USA: CRC Press; 2007:778. ISBN-10: 1420067494 ISBN-13: 978-1420067491 Edition: 1