Regulation of microRNA expression and function by nuclear receptor signaling

Cell & Bioscience

Li Wang¹  Zhihong Yang¹ 

[1] Departments of Medicine and Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84132, USA

关键词: gene regulation;    nuclear receptors;    miRNAs;   

Others  :  793876
DOI  :  10.1186/2045-3701-1-31

 received in 2011-07-11, accepted in 2011-09-21,  发布年份 2011

【 摘 要 】

MicroRNAs (miRNAs) are small non-coding RNA transcripts that affect various cellular pathways by serving as regulators of gene expression at the translational and transcriptional level. Nuclear receptors (NRs) are ligand-activated transcription factors that regulate gene transcription by binding to the promoter region or by interacting with other transcription factors. NRs can regulate miRNA expression either at the transcriptional level, or through posttranscriptional maturation by interacting with miRNA processing factors. This review will summarize recent advances in knowledge of the modulation of miRNA expression by NRs. Increased understanding of the molecular basis of miRNA expression may enable new therapeutic interventions that modulate miRNA activities through NR-mediated signaling.

【 授权许可】

   
2011 Yang and Wang; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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