Poorer glycaemic control is associated with increased skin thickness at injection sites in children with type 1 diabetes

International Journal of Pediatric Endocrinology

Paul L Hofman⁵  Craig Jefferies⁴  Jane M Peart³  Wayne S Cutfield⁵  Marius Rademaker²  José G B Derraik¹ 

[1] Liggins Institute, University of Auckland, Auckland, New Zealand;Dermatology Department, Waikato Hospital, Hamilton, New Zealand;Auckland Radiology Group, Auckland, New Zealand;Starship Children’s Hospital, Auckland District Health Board, Auckland, New Zealand;Gravida: National Centre for Growth and Development, Auckland, New Zealand

关键词: HbA1c;    Subcutis;    Subcutaneous tissue;    Dermis;    Type 1 diabetes;   

Others  :  811393
DOI  :  10.1186/1687-9856-2014-2

 received in 2013-11-11, accepted in 2014-02-20,  发布年份 2014

【 摘 要 】

We aimed to assess the association between skin thickness and glycaemic control in children with type 1 diabetes. Forty-five children (51% males) aged 10.5 ± 2.1 years were studied. Thickness of skin layers were determined by ultrasonography, with participants having ultrasound scans of three anatomical regions (abdomen, thigh, and buttocks). Poorer glycaemic control (increasing HbA1c values) was associated with greater thickness of the dermis (p = 0.015), with an estimated thickening of 87 μm with every 1% increase in HbA1c. Our data suggest that dermal changes associated with poorer glycaemic control in adults are also observed in childhood.

【 授权许可】

   
2014 Derraik et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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