Bovine papillomavirus on the scene of crime: is E5 oncogene the only guilty party?

Infectious Agents and Cancer

Giuseppe Borzacchiello¹ 

[1] Department of Veterinary medicine and Animal productions, University of Naples Federico II, Via F. Delpino, 1-80137, Naples, Italy

关键词: E7;    E6;    E5;    Bovine papillomavirus;   

Others  :  802880
DOI  :  10.1186/1750-9378-8-26

 received in 2013-05-10, accepted in 2013-07-01,  发布年份 2013

【 摘 要 】

Bovine papillomaviruses (BPVs) induce hyperplastic and tumoral lesions not only in cows but also in other different animal species. The transforming activity of BPVs is due to its major E5 oncogene. Recent studies have highlighted the role of E5 in cancer development but very little is known about E6 and E7 oncogenes. In this letter we argue for the need of investigating E6 as well as E7 to better understand the role of these two oncogenes during carcinogenesis.

【 授权许可】

   
2013 Borzacchiello; licensee BioMed Central Ltd.

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