Genetic association of APOA5 and APOE with metabolic syndrome and their interaction with health-related behavior in Korean men

Lipids in Health and Disease

Jong-Il Kim¹  Jin Ho Park⁴  BeLong Cho⁴  Jae Moon Yun⁴  SeSong Jang²  Jinha Hwang²  Jeesoo Chae²  Ho-Young Son³  Ki Young Son⁴ 

[1] Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea;Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea;Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Republic of Korea;Health Promotion Center, Seoul National University Hospital, Seoul, Republic of Korea

关键词: Triglyceride;    Metabolic syndrome;    Health behavior;    APOE;    APOA5;   

Others  :  1234435
DOI  :  10.1186/s12944-015-0111-5

 received in 2015-07-14, accepted in 2015-08-31,  发布年份 2015

【 摘 要 】

Background

Genome-wide association studies have been used extensively to identify genetic variants linked to metabolic syndrome (MetS), but most of them have been conducted in non-Asian populations. This study aimed to evaluate the association between MetS and previously studied single nucleotide polymorphisms (SNPs), and their interaction with health-related behavior in Korean men.

Methods

Seventeen SNPs were genotyped and their association with MetS and its components was tested in 1193 men who enrolled in the study at Seoul National University Hospital.

Results

We found that rs662799 near APOA5 and rs769450 in APOE had significant association with MetS and its components. The SNP rs662799 was associated with increased risk of MetS, elevated triglyceride (TG) and low levels of high-density lipoprotein, while rs769450 was associated with a decreased risk of TG. The SNPs showed interactions between alcohol drinking and physical activity, and TG levels in Korean men.

Conclusions

We have identified the genetic association and environmental interaction for MetS in Korean men. These results suggest that a strategy of prevention and treatment should be tailored to personal genotype and the population.

【 授权许可】

   
2015 Son et al.

【 图 表 】

Fig. 1.

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