Optimizing purebred selection for crossbred performance using QTL with different degrees of dominance

Genetics Selection Evolution

Reena Chakraborty¹  Jack CM Dekkers¹ 

[1] Department of Animal Science, 225C Kildee Hall, Iowa State University, Ames, IA, 50011, USA

关键词: marker assisted selection;    quantitative trait loci;    selection;    crossbreeding;   

Others  :  1094328
DOI  :  10.1186/1297-9686-36-3-297

 received in 2003-04-09, accepted in 2003-12-17,  发布年份 2004

【 摘 要 】

A method was developed to optimize simultaneous selection for a quantitative trait with a known QTL within a male and a female line to maximize crossbred performance from a two-way cross. Strategies to maximize cumulative discounted response in crossbred performance over ten generations were derived by optimizing weights in an index of a QTL and phenotype. Strategies were compared to selection on purebred phenotype. Extra responses were limited for QTL with additive and partial dominance effects, but substantial for QTL with over-dominance, for which optimal QTL selection resulted in differential selection in male and female lines to increase the frequency of heterozygotes and polygenic responses. For over-dominant QTL, maximization of crossbred performance one generation at a time resulted in similar responses as optimization across all generations and simultaneous optimal selection in a male and female line resulted in greater response than optimal selection within a single line without crossbreeding. Results show that strategic use of information on over-dominant QTL can enhance crossbred performance without crossbred testing.

【 授权许可】

   
2004 INRA, EDP Sciences