Tumor suppressor gene E-cadherin and its role in normal and malignant cells

Cancer Cell International

Nives Pećina-Šlaus¹ 

[1] Department of Biology, School of Medicine, University of Zagreb, Šalata 3, HR-10000 Zagreb, Croatia

关键词: wnt signalling;    cell adhesion;    CDH1;    E-cadherin;   

Others  :  796062
DOI  :  10.1186/1475-2867-3-17

 received in 2003-09-17, accepted in 2003-10-14,  发布年份 2003

【 摘 要 】

E-cadherin tumor suppressor genes are particularly active area of research in development and tumorigenesis. The calcium-dependent interactions among E-cadherin molecules are critical for the formation and maintenance of adherent junctions in areas of epithelial cell-cell contact. Loss of E-cadherin-mediated-adhesion characterises the transition from benign lesions to invasive, metastatic cancer. Nevertheless, there is evidence that E-cadherins may also play a role in the wnt signal transduction pathway, together with other key molecules involved in it, such as beta-catenins and adenomatous poliposis coli gene products.

The structure and function of E-cadherin, gene and protein, in normal as well as in tumor cells are reviewed in this paper.

【 授权许可】

   
2003 Pećina-Šlaus; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

【 图 表 】

Figure 1.

Figure 2.

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