High gamma activity of 60–70 Hz in the area surrounding a cortical tuber in an infant with tuberous sclerosis

Italian Journal of Pediatrics

Taisuke Otsuki²  Akio Takahashi²  Yu Kaneko²  Takanobu Kaido²  Masayuki Sasaki¹  Kenji Sugai¹  Ryoko Honda¹  Eiji Nakagawa¹  Kaori Irahara³ 

[1] Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry (NCNP), 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo, 187-8551, Japan;Department of Neurosurgery, National Center Hospital, NCNP, Tokyo, Japan;Department of Pediatrics, Shimada Ryoiku Center, Tokyo, Japan

关键词: Scalp electroencephalogram;    Multiple band frequency analysis;    Frequency oscillations;    Periodic spasms;    Tuberous sclerosis;   

Others  :  826009
DOI  :  10.1186/1824-7288-38-15

 received in 2012-01-20, accepted in 2012-05-03,  发布年份 2012

【 摘 要 】

Purpose

To detect the epileptogenic region causing epileptic spasms in an infant with tuberous sclerosis (TS).

Methods

We applied a multiple band frequency analysis to video electroencephalographic (EEG) recordings of the infant’s scalp. We also performed computed tomography (CT), magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), and magnetoencephalography (MEG) of the brain in order to ascertain the epileptic focus.

Results

During the periodic spasms, we identified fast ictal activity with frequencies of 60–70 Hz in the right centroparietal region. This region was part of the area surrounding the largest cortical tuber that was identified on CT and MRI and was located in the right frontal lobe. An area of increased blood perfusion that was observed with SPECT and dipole sources that were determined with interictal MEG were also located in this area. In addition, ictal frequency oscillations (FOs) with high gamma activity were identified over the cortex surrounding the largest tuber. After a lesionectomy of this tuber, the periodic spasms disappeared, and no FOs were detected over this area.

Conclusions

Scalp EEG, which identified the ictal onset zone by detecting fast activity that was suggestive of FOs, was useful for detecting the epileptogenic region in an infant with TS.

【 授权许可】

   
2012 Irahara et al.; licensee BioMed Central Ltd.

【 图 表 】

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