期刊论文详细信息
Journal of Cardiothoracic Surgery
Factors affecting postoperative blood loss in children undergoing cardiac surgery
Philippe Van der Linden1  David Faraoni1 
[1] Department of Anesthesiology, Centre Hospitalier Universitaire (CHU) Brugmann - Queen Fabiola Children’s University Hospital (QFCUH), Free University of Brussels, 15 JJ Crocq Av. 1020, Brussels, Belgium
关键词: Point-of-care monitoring;    Age;    Bleeding management;    Congenital heart surgery;   
Others  :  811724
DOI  :  10.1186/1749-8090-9-32
 received in 2013-10-16, accepted in 2014-02-05,  发布年份 2014
PDF
【 摘 要 】

We hypothesized that the influence of cyanotic disease on postoperative blood loss is closely related to age in children undergoing cardiac surgery. Here, we demonstrate that the presence of a cyanotic disease is associated with increased postoperative blood loss in children aged 1 to 6 months. Children with cyanotic disease and aged < 1 month who received fresh frozen plasma during cardiopulmonary bypass had less postoperative blood loss and higher maximal clot firmness on FIBTEM than cyanotic children from all other groups. Additional studies are needed to define optimal pathophysiology-based management in children undergoing cardiac surgery.

【 授权许可】

   
2014 Faraoni and Van der Linden; licensee BioMed Central Ltd.

【 预 览 】
附件列表
Files Size Format View
20140709071613442.pdf 727KB PDF download
Figure 2. 53KB Image download
Figure 1. 27KB Image download
【 图 表 】

Figure 1.

Figure 2.

【 参考文献 】
  • [1]Despotis GJ, Gravlee G, Filos K, Levy J: Anticoagulation monitoring during cardiac surgery: a review of current and emerging techniques. Anesthesiology 1999, 91:1122-1151.
  • [2]Guzzetta NA, Miller BE: Principles of hemostasis in children: models and maturation. Paediatr Anaesth 2011, 21:3-9.
  • [3]Miller BE, Mochizuki T, Levy JH, et al.: Predicting and treating coagulopathies after cardiopulmonary bypass in children. Anesth Analg 1997, 85:1196-1202.
  • [4]Eaton MP, Iannoli EM: Coagulation considerations for infants and children undergoing cardiopulmonary bypass. Paediatr Anaesth 2011, 21:31-42.
  • [5]Osthaus WA, Boethig D, Johanning K, et al.: Whole blood coagulation measured by modified thrombelastography (ROTEM) is impaired in infants with congenital heart diseases. Blood Coagul Fibrinolysis 2008, 19:220-225.
  • [6]Oswald E, Stalzer B, Heitz E, et al.: Thromboelastometry (ROTEM) in children: age-related reference ranges and correlations with standard coagulation tests. Br J Anaesth 2010, 105:827-835.
  • [7]Hanart C, Khalife M, De Ville A, Otte F, De Hert S, Van der Linden P: Perioperative volume replacement in children undergoing cardiac surgery: albumin versus hydroxyethyl starch 130/0.4. Crit Care Med 2009, 37:696-701.
  • [8]Tempe DK, Virmani S: Coagulation abnormalities in patients with cyanotic congenital heart disease. J Cardiothorac Vasc Anesth 2002, 16:752-765.
  • [9]Jenkins KJ, Gauvreau K, Newburger JW, Spray TL, Moller JH, Iezzoni LI: Consensus-based method for risk adjustment for surgery for congenital heart disease. J Thorac Cardiovasc Surg 2002, 123:110-118.
  • [10]Jensen AS, Johansson PI, Bochsen L, Idorn L, Sorensen KE, Thilen U, Nagy E, Furenas E, Sondergaard L: Fibrinogen function is impaired in whole blood from patients with cyanotic congenital heart disease. Int J Cardiol 2012. doi:10.1016/j.ijcard.2012.06.019
  • [11]Hofer A, Kozek-Langenecker S, Schaden E, Panholzer M, Gombotz H: Point-of-care assessment of platelet aggregation in paediatric open heart surgery. Br J Anaesth 2011, 107:587-592.
  • [12]Ranucci M, Carlucci C, Isgro G, Baryshnikova E: A prospective pilot study of platelet function and its relationship with postoperative bleeding in pediatric cardiac surgery. Minerva Anestesiol 2012, 78:556-563.
  • [13]Levy JH, Welsby I, Goodnough LT: Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy. Transfusion 2013. doi: 10.1111/trf.12431
  • [14]Rahe-Meyer N, Solomon C, Hanke A, et al.: Effects of fibrinogen concentrate as first-line therapy during major aortic replacement surgery: a randomized, placebo-controlled trial. Anesthesiology 2013, 118:40-50.
  文献评价指标  
  下载次数:9次 浏览次数:8次