Summary of papers presented at the 2012 seventh international cough symposium

Cough

Milos Tatar³  Lu-Yuan Lee²  Giovanni A Fontana⁴  Peter V Dicpinigaitis¹ 

[1] Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA;Department of Physiology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536-0298, USA;Department of Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia;Department of Internal Medicine, University of Florence, Florence, Italy

关键词: Treatment;    Symptom assessment;    Aspiration pneumonia;    GERD;    High altitude;    Brainstem;    Mouse;    Stem cells;    Cough suppressant;   

Others  :  809246
DOI  :  10.1186/1745-9974-9-13

 received in 2013-01-08, accepted in 2013-03-20,  发布年份 2013

【 摘 要 】

Twenty six papers were presented as posters in the Seventh International Symposium on Cough; 12 papers were presented in the Basic Science of Cough session, and 14 papers presented in the Clinical Science of Cough session. These papers explored a wide spectrum of cough-related areas including pathophysiological mechanisms, treatment and detection of cough, and symptom assessment and perception, and were grouped into several general themes for facilitate the discussion. Studies presented in these posters have provided new information that should improve our knowledge on the basic physiology and pharmacology of cough, and the peripheral and central neural mechanisms involved in the generation of the cough motor pattern. In addition, in the clinical science section, studies reporting potential new anti-tussive agents and further characterisation of cough symptoms and perception have provided a base for the fruitful strategies for the development of novel anti-tussive therapies and cough management.

【 授权许可】

   
2013 Dicpinigaitis et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Ikegami K, Sato S, Nakamura K, Ostrowski LE, Setou M: Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry. Proc Natl Acad Sci U S A 2010, 107:10490-10495.
• [2]Mason NP, Barry PW, Despiau G, Gardette B, Richalet JP: Cough frequency and cough receptor sensitivity to citric acid challenge during a simulated ascent to extreme altitude. Eur Respir J 1999, 13:508-513.
• [3]Karlsson JA, Sant’Ambrogio G, Widdicombe J: Afferent neural pathways in cough and reflex bronchoconstriction. J Appl Physiol 1988, 65:1007-1023.
• [4]Morice AH, Fontana GA, Belvisi MG, Birring SS, Chung KF, Dicpinigaitis PV, Kastelik JA, McGarvey LP, Smith JA, Tatar M, Widdicombe J, European Respiratory Society (ERS): ERS guidelines on the assessment of cough. Eur Respir J 2007, 29:1256-1276.
• [5]Catalano F, Terminella C, Grillo C, Biondi S, Zappalà M, Bentivegna C: Prevalence of oesophagitis in patients with persistent upper respiratory symptoms. J Laryngol Otol 2004, 118:857-861.
• [6]Zhong C, Duan L, Wang K, Xu Z, Ge Y, Yang C, Han Y: Esophageal intraluminal baseline impedance is associated with severity of acid reflux and epithelial structural abnormalities in patients with gastroesophageal reflux disease. J Gastroenterol 2012. Epub ahead of print
• [7]Eldridge FL, Millhorn DE, Waldrop TG: Input–output relationships of the central respiratory controller during peripheral muscle stimulation in cats. J Physiol 1982, 324:285-295.
• [8]Pearson JP, Parikh S, Orlando RC, Johnston N, Allen J, Tinling SP, Johnston N, Belafsky P, Arevalo LF, Sharma N, Castell DO, Fox M, Harding SM, Morice AH, Watson MG, Shields MD, Bateman N, McCallion WA, van Wijk MP, Wenzl TG, Karkos PD, Belafsky PC: Review article: reflux and its consequences--the laryngeal, pulmonary and oesophageal manifestations. Conference held in conjunction with the 9th International Symposium on Human Pepsin (ISHP) Kingston-upon-Hull, UK, 21–23 April 2010. Aliment Pharmacol Ther 2011, 33(Suppl 1):1-71.
• [9]Poussel M, Varechova S, Demoulin B, Chalon B, Schweitzer C, Marchal F, Chenuel B: Nasal stimulation by water down-regulates cough in anesthetized rabbits. Respir Physiol Neurobiol 2012, 183:20-25.
• [10]Dicpinigaitis PV: Cough: an unmet clinical need. Br J Pharmacol 2011, 163:116-124.
• [11]Grace MS, Dubuis E, Birrell MA, Belvisi MG: TRP channel antagonists as potential antitussives. Lung 2012, 190:11-15.
• [12]Ryan NM, Birring SS, Gibson PG: Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial. Lancet 2012, 380:1583-1589.