HOX genes in ovarian cancer

Journal of Ovarian Research

Richard GL Morgan¹  Hardev S Pandha¹  Simon Butler-Manuel²  Agnieszka Michael¹  Zoë L Kelly¹ 

[1] Postgraduate Medical School, Faculty of Health and Medical Sciences, University of Surrey, GU2 7WG, UK;Royal Surrey County Hospital, Egerton Road, Guildford, Surrey, GU2 7XX, UK

关键词: HXR9;    Therapy;    HOX;    Cancer;    Ovarian;   

Others  :  824443
DOI  :  10.1186/1757-2215-4-16

 received in 2011-06-28, accepted in 2011-09-09,  发布年份 2011

【 摘 要 】

The HOX genes are a family of homeodomain-containing transcription factors that determine cellular identity during development. Here we review a number of recent studies showing that HOX genes are strongly expressed in ovarian cancer, and that in some cases the expression of specific HOX genes is sufficient to confer a particular identity and phenotype upon cancer cells. We also review the recent advances in elucidating the different functions of HOX genes in ovarian cancer. A literature search was performed using the search terms HOX genes (including specific HOX genes), ovarian cancer and oncogenesis. Articles were accessed through searches performed in ISI Web of Knowledge, PubMed and ScienceDirect. Taken together, these studies have shown that HOX genes play a role in the oncogenesis of ovarian cancer and function in the inhibition of apoptosis, DNA repair and enhanced cell motility. The function of HOX genes in ovarian cancer oncogenesis supports their potential role as prognostic and diagnostic markers, and as therapeutic targets in this disease.

【 授权许可】

   
2011 Kelly et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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