CEBPA-regulated lncRNAs, new players in the study of acute myeloid leukemia

Journal of Hematology & Oncology

Alessandro Fatica²  Irene Bozzoni¹  Federico M Giorgi³  Beatrice Salvatori³  James M Hughes² 

[1] Institute Pasteur Fondazione Cenci-Bolognetti, Sapienza University of Rome, Rome, 00185, Italy;Department of Biology and Biotechnology C. Darwin, Sapienza University of Rome, Rome, 00185, Italy;Department of Systems Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, Columbia, New York, USA

关键词: AML;    CEBPA;    lncRNAs;   

Others  :  1144298
DOI  :  10.1186/s13045-014-0069-1

 received in 2014-09-01, accepted in 2014-09-16,  发布年份 2014

【 摘 要 】

CCAAT/enhancer-binding protein-? (CEBPA) is a critical regulator of myeloid differentiation. Disruption of CEBPA function contributes to the development of acute myeloid leukemia (AML). CEBPA regulates a large number of protein coding genes of which several were shown to contribute to CEBPA function. In this study, we expand the analysis of CEBPA transcriptional targets to the newly identified class of long non-coding RNAs. We show that lncRNAs are a main component of the transcriptional program driven by C/EBP? and that many of these are also induced during granulocytic differentiation of AML cell lines supporting their relevance in proliferation arrest and differentiation.

【 授权许可】

   
2014 Hughes et al.; licensee BioMed Central Ltd.

【 图 表 】

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