Histone H3 lysine 4 methyltransferases and demethylases in self-renewal anddifferentiation of stem cells

Cell & Bioscience

Min Gyu Lee¹  Bingnan Gu¹ 

[1] Department of Molecular and Cellular Oncology, The University of Texas MDAnderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA

关键词: Differentiation;    Self-renewal;    Stem cell;    Demethylase;    Methyltransferase;    H3K4;    Histone methylation;   

Others  :  791507
DOI  :  10.1186/2045-3701-3-39

 received in 2013-06-17, accepted in 2013-07-27,  发布年份 2013

【 摘 要 】

Epigenetic mechanisms are fundamental to understanding the regulatory networks of gene expression that govern stem cell maintenance and differentiation. Methylated histone H3 lysine 4 (H3K4) has emerged as a key epigenetic signal for gene transcription; it is dynamically modulated by several specific H3K4 methyltransferases and demethylases. Recent studies have described new epigenetic mechanisms by which H3K4 methylation modifiers control self-renewal and lineage commitments of stem cells. Such advances in stem cell biology would have a high impact on the research fields of cancer stem cell and regenerative medicine. In this review, we discuss the recent progress in understanding the roles of H3K4 methylation modifiers in regulating embryonic and adult stem cells’ fates.

【 授权许可】

   
2013 Gu and Lee; licensee BioMed Central Ltd.

【 图 表 】

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