Selection against genetic defects in conservation schemes while controlling inbreeding

Genetics Selection Evolution

Theo HE Meuwissen¹  Luc LG Janss¹  Anna K Sonesson² 

[1] Institute of Animal Science and Health (ID-Lelystad), PO Box 65, 8200 AB Lelystad, The Netherlands;AKVAFORSK (Institute of Aquaculture Research Ltd), PO Box 5010, 1432 Ås, Norway

关键词: conservation;    inbreeding;    selection;    genetic defects;   

Others  :  1094430
DOI  :  10.1186/1297-9686-35-5-353

 received in 2002-04-09, accepted in 2003-01-15,  发布年份 2003

【 摘 要 】

We studied different genetic models and evaluation systems to select against a genetic disease with additive, recessive or polygenic inheritance in genetic conservation schemes. When using optimum contribution selection with a restriction on the rate of inbreeding (ΔF) to select against a disease allele, selection directly on DNA-genotypes is, as expected, the most efficient strategy. Selection for BLUP or segregation analysis breeding value estimates both need 1–2 generations more to halve the frequency of the disease allele, while these methods do not require knowledge of the disease mutation at the DNA level. BLUP and segregation analysis methods were equally efficient when selecting against a disease with single gene or complex polygene inheritance, i.e. knowledge about the mode of inheritance of the disease was not needed for efficient selection against the disease. Smaller schemes or schemes with a more stringent restriction on ΔF needed more generations to halve the frequency of the disease alleles or the fraction of diseased animals. Optimum contribution selection maintained ΔF at its predefined level, even when selection of females was at random. It is argued that in the investigated small conservation schemes with selection against a genetic defect, control of ΔF is very important.

【 授权许可】

   
2003 INRA, EDP Sciences