Renal-type clear cell carcinoma of the prostate: a diagnostic challenge

Diagnostic Pathology

Uday Shankar Dwivedi¹  Sameer Trivedi¹  Richa Katiyar²  Nidhi Johri²  Shashikant C. U. Patne² 

[1] Department of Urology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, UP, India;Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, UP, India

关键词: Prostatic neoplasms;    Prostatectomy;    Prostate-specific antigen;    Male;    Renal cell carcinoma;   

Others  :  1233631
DOI  :  10.1186/s13000-015-0432-8

 received in 2015-08-22, accepted in 2015-10-17,  发布年份 2015

【 摘 要 】

A 72-year-old male presented with urinary symptoms. His serum prostate specific antigen level was 65.2 ng/ml. His radical prostatectomy specimen showed clear cell lesion reminiscent of the clear cell renal cell carcinoma along with acinar type of prostatic adenocarcinoma, Gleason score 4 + 4. The lesional clear cells were positive for pancytokeratin, epithelial membrane antigen, CD10, vimentin, and AMACR while negative for 34βE12, CK7, prostate specific antigen, and PAX8. The final diagnosis was renal-type clear cell carcinoma of the prostate. A follow-up of 20 months did not show metastasis. We herein report fifth case of renal-type clear cell carcinoma of the prostate.

【 授权许可】

   
2015 Patne et al.

【 图 表 】

Fig. 1.

【 参考文献 】

• [1]Humphrey PA. Clear cell neoplasms of the urinary tract and male reproductive system. Semin Diagn Pathol. 1997; 14:240-52.
• [2]Singh H, Flores-Sandoval N, Abrams J. Renal-type clear cell carcinoma occurring in the prostate. Am J Surg Pathol. 2003; 27:407-10.
• [3]Pal DK, Chowdhury MK. Renal type clear cell carcinoma of prostate. Indian J Surg. 2007; 69:81.
• [4]Permi H, Laxminarayana KP, Yeshvanth S, Shetty J. Renal type clear cell carcinoma of the prostate: a diagnostic dilemma. J Lab Physicians. 2011; 3:132-3.
• [5]Wang Q, Xue Y. Renal-type clear cell carcinoma of the prostate: a case report. Oncol Lett. 2015; 9:2149-52.
• [6]Sangoi AR, Fujiwara M, West RB, Montgomery KD, Bonventre JV, Higgins JP et al.. Immunohistochemical distinction of primary adrenal cortical lesions from metastatic clear cell renal cell carcinoma: a study of 248 cases. Am J Surg Pathol. 2011; 35:678-86.
• [7]Cihak RW, Haas R, Koenen CT, Chinchinian H. Metastatic renal carcinoma to the prostate gland: presentation as prostatic hypertrophy. J Urol. 1980; 123:791-2.
• [8]King DH, Centeno AS, Saldivar VA, Sarosdy MF. Renal cell carcinoma metastatic to the gallbladder or prostate: two case reports. Urology. 1995; 46:722-5.