Lifestyle advice follow-up improve glycemic control, redox and inflammatory status in patients with type 2 diabetes

Journal of Diabetes & Metabolic Disorders

Malika Bouchenak¹  Zakaria Benzian²  Farida Ouda Boukortt¹  Nadia Mahdad¹ 

[1] Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences de la Nature et de la Vie, Université d’Oran, Oran, 31 000, Algeria;Clinique Laribère, Centre Hospitalo-Universitaire CHU, Oran, 31 000, Algeria

关键词: TNF-α;    Resistin;    Redox status;    HbA1c;    Type 2 diabetes;   

Others  :  1133453
DOI  :  10.1186/s40200-014-0122-1

 received in 2014-03-18, accepted in 2014-12-09,  发布年份 2014

【 摘 要 】

Background

The dietary composition associated to physical activity could play a significant role in improving insulin sensitivity and reducing risk of diabetes and its complications. This study was designed to investigate whether glycemic control, redox and inflammatory status impairments in patients with type 2 diabetes (T2D), were improved after 90 (d90) and 180 (d180) days follow-up of nutritional advices.

Methods

Patients with T2D (n = 85) aged of 50 ± 8 years (Female/Male, 45/40), treated with oral antidiabetics (OAD) alone, with a body mass index (BMI) of 26 ± 2, were recruited. At the beginning of the study (d0), patients were instructed to follow-up nutritional advices adapted to T2D, and 30 to 45 min of walking per day. Assays were realized at d90 and d180 of follow-up. Data were compared by student ‘t’ test and Pearson’s correlation coefficients were determined between biochemical parameters and nutritional advices follow-up.

Results

Reduced glycated haemoglobin (HbA1c), glucose and total cholesterol (TC) were noted in patients with T2D, at d90 and d180 compared to d0. Thiobarbituric acid reactive substances (TBARS) and hydroperoxyde levels were lower at d90 and d180 than d0. Serum nitric oxide (NO) was decreased at d180 compared to d0 and d90. In erythrocytes, superoxide dismutase (SOD) activity increased by 7% at d180 vs d0. Moreover, activity of glutathione peroxidase (GPx) enhanced (P < 0.05), whereas that of glutathione reductase (GRed) decreased (P < 0.001) at d90 vs d0. Resistin values were lower at d180 than d0 and d90 (P < 0.001). A progressive decrease in tumor necrosis factor-α (TNF-α) was observed at d90 and d180 vs d0.

Conclusion

Nutritional advices associated to physical activity improve glycemic control, serum TC, redox and inflammatory status in T2D, in particular after 3 months of counseling. However, these results need to be supported with a longer dietary treatment and more rigorous control during the follow-up.

【 授权许可】

   
2014 Mahdad et al.; licensee BioMed Central.

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