α-Amylase inhibitory activity of some traditionally used medicinal species of Labiatae

Journal of Diabetes & Metabolic Disorders

Soodabeh Saeidnia⁴  Mahdieh Kurepaz-Mahmoodabadi²  Ahmad Reza Gohari⁴  Parisa Sarkhail³  Gholamreza Amin¹  Marjan Nikan²  Hedieh Safamansouri² 

[1] Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran, Iran;Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran;Division of Pharmacy, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada

关键词: Hymenocrater;    Stachys;    Scutellarua;    Salvia;    Satureja;    Phlomis;    α-amylase inhibitory;   

Others  :  1135818
DOI  :  10.1186/s40200-014-0114-1

 received in 2014-06-30, accepted in 2014-11-20,  发布年份 2014

【 摘 要 】

Background

Natural α-amylase inhibitors of herbal origin are an attractive therapeutic approach to control post-prandial hyperglycemia via reducing the glucose release from starch and delaying carbohydrate absorption. These compounds are able to inhibit the activity of the carbohydrate hydrolyzing enzymes in the small intestine and potentially useful in control of diabetes. The enlarged Lamiaceae (Labiatae) family contains about 6,900 to 7,200 species worldwide and many species of this family possess medicinal properties and have been used traditionally for treatment of chronic illnesses including diabetes.

Methods

In the present study particular species of Labiatae family from the genera, Phlomis, Satureja, Salvia, Scutellarua, Stachys and Hymenocrater, which are growing wildly in Iran, selected to evaluate for possible in vitro α-amylase inhibitory activity, compared to acarbose as a positive control.

Results

The inhibitory activities of all the herbal extracts were varied from 1.9 to 18.6 (IC50, μg/mL). Additionally, the ethyl acetate extract of P. bruguieri (IC50 = 1.9 μg/mL) and the butanol extract of P. persica (IC50 = 3.6 μg/mL) exhibited the lowest IC50 values among all the species as the most potent herbal extracts, while the inhibitory activity of S. sahendica and S. macrosiphon (ethyl acetate extracts) as well as P. caucasica (butanol extract) on α-amylase enzyme was observed as weak and did not reach at least to the 50% of the enzyme inhibition level.

Conclusions

Taking together, P. bruguieri and P. persica among the Phlomis species can be the promising sources of α-amylase inhibitors. However, P. rigida, S. bizantina and H. bituminosus that exhibited moderate activity can be stand on second level of interest.

【 授权许可】

   
2014 Safamansouri et al.; licensee BioMed Central.

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