Osseointegration of porous titanium implants with and without electrochemically deposited DCPD coating in an ovine model

Journal of Orthopaedic Surgery and Research

William R Walsh¹  Haruo Kawamura³  Hajime Mishima²  Tomofumi Nishino²  Naoya Taki⁴  Abe Lau¹  Nicky Bertollo¹  Dong Chen¹ 

[1] Surgical & Orthopaedic Research Laboratories, Prince of Wales Hospital, University of New South Wales, Sydney, Australia;University of Tsukuba, Tsukuba, Japan;Ryugasaki Saiseikai Hospital, Ryugasaki, Japan;Yokohama City University Medical Center, Yokohama, Japan

关键词: Bone remodeling;    Osteoconduction;    Calcium phosphate;    Interfacial shear strength;    Bone ingrowth;   

Others  :  823438
DOI  :  10.1186/1749-799X-6-56

 received in 2011-03-23, accepted in 2011-11-03,  发布年份 2011

【 摘 要 】

Background

Uncemented fixation of components in joint arthroplasty is achieved primarily through de novo bone formation at the bone-implant interface and establishment of a biological and mechanical interlock. In order to enhance bone-implant integration osteoconductive coatings and the methods of application thereof are continuously being developed and applied to highly porous and roughened implant substrates. In this study the effects of an electrochemically-deposited dicalcium phosphate dihydrate (DCPD) coating of a porous substrate on implant osseointegration was assessed using a standard uncemented implant fixation model in sheep.

Methods

Plasma sprayed titanium implants with and without a DCPD coating were inserted into defects drilled into the cancellous and cortical sites of the femur and tibia. Cancellous implants were inserted in a press-fit scenario whilst cortical implants were inserted in a line-to-line fit. Specimens were retrieved at 1, 2, 4, 8 and 12 weeks postoperatively. Interfacial shear-strength of the cortical sites was assessed using a push-out test, whilst bone ingrowth, ongrowth and remodelling were investigated using histologic and histomorphometric endpoints.

Results

DCPD coating significantly improved cancellous bone ingrowth at 4 weeks but had no significant effect on mechanical stability in cortical bone up to 12 weeks postoperatively. Whilst a significant reduction in cancellous bone ongrowth was observed from 4 to 12 weeks for the DCPD coating, no other statistically significant differences in ongrowth or ingrowth in either the cancellous or cortical sites were observed between TiPS and DCPD groups.

Conclusion

The application of a DCPD coating to porous titanium substrates may improve the extent of cancellous bone ingrowth in the early postoperative phase following uncemented arthroplasty.

【 授权许可】

   
2011 Chen et al; licensee BioMed Central Ltd.

【 图 表 】

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