High plasma levels of high mobility group box 1 is associated with the risk of sepsis in severe blunt chest trauma patients: a prospective cohort study

Journal of Cardiothoracic Surgery

Zhi-Qian Lu³  Xiao-Yong Xiang²  Xing-Ji Zhao¹  Avash Karki²  Xiao-Wen Wang³ 

[1] Department of Traumatic Surgery, Chongqing Emergency Medical Center, Chongqing 400016, China;Department of Cardiothoracic Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, PR China;Department of Cardiothoracic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, NO. 600 Yishan Road, Shanghai 200233, PR China

关键词: Complications;    MODS;    Sepsis;    Inflammation;    High-mobility group box 1;    Chest trauma;   

Others  :  1152211
DOI  :  10.1186/s13019-014-0133-5

 received in 2014-02-01, accepted in 2014-07-17,  发布年份 2014

【 摘 要 】

Background

High mobility group box 1 (HMGB1) is a late mediator of systemic inflammation. Extracellular HMGB1 play a central pathogenic role in critical illness. The purpose of the study was to investigate the association between plasma HMGB1 concentrations and the risk of poor outcomes in patients with severe blunt chest trauma.

Methods

The plasma concentrations of HMGB1 in patients with severe blunt chest trauma (AIS ≥ 3) were measured by a quantitative enzyme-linked immunosorbent assay at four time points during seven days after admission, and the dynamic release patterns were monitored. The biomarker levels were compared between patients with sepsis and non-sepsis, and between patients with multiple organ dysfunction syndrome (MODS) and non-MODS. The related factors of prognosis were analyzed by using multivariate logistic regression analysis. The short-form 36 was used to evaluate the quality of life of patients at 12 months after injury.

Results

Plasma HMGB1 levels were significantly higher both in sepsis and MODS group on post-trauma day 3, 5, and 7 compared with the non-sepsis and non-MODS groups, respectively. Multivariate analysis showed that HMGB1 levels and ISS were independent risk factors for sepsis and MODS in patients with severe blunt chest trauma.

Conclusions

Plasma HMGB1 levels were significantly elevated in patients with severe blunt chest trauma. HMGB1 levels were associated with the risk of poor outcome in patients with severe blunt chest trauma. Daily HMGB1 levels measurements is a potential useful tool in the early identification of post-trauma complications. Further studies are needed to determine whether HMGB1 intervention could prevent the development of sepsis and MODS in patients with severe blunt chest trauma.

【 授权许可】

   
2014 Lu et al.; licensee BioMed Central

【 图 表 】

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