Significance of red cell distribution width measurement for the patients with isolated coronary artery ectasia

Journal of Translational Medicine

Jian-Jun Li¹  Li-Xin Jiang¹  Cheng-Gang Zhu¹  Rui-Xia Xu¹  Yuan-Lin Guo¹  Shao-Ping Nie³  Yan-Jun Jia¹  Li-Feng Hong²  Xiao-Lin Li¹ 

[1] Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China;Department of Cardiology, Fifth Hospital of Wuhan City, Wuhan 430050, China;Department of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China

关键词: C-reactive protein;    Coronary artery disease;    Coronary artery ectasia;    Red cell distribution width;   

Others  :  817739
DOI  :  10.1186/1479-5876-12-62

 received in 2013-10-31, accepted in 2014-03-03,  发布年份 2014

【 摘 要 】

Background

Red cell distribution width (RDW) has been recognized as a novel marker for several cardiovascular diseases. The aim of this study was to evaluate the association between RDW levels and the presence of isolated coronary artery ectasia (CAE).

Methods

We studied 414 subjects including 113 patients with isolated CAE (Group A), 144 patients with coronary artery disease (CAD, group B) and 157 angiographically normal controls (group C). Baseline clinical characteristics and laboratory findings including RDW were compared among three groups.

Results

The levels of RDW were significantly higher in group A and B compared with that in group C (12.97 ± 1.4 and 12.88 ± 1.0 vs 12.34 ± 0.9, p = 0.020) while no difference was found between CAE and CAD (p = 0.17). Additionally, the levels of CRP were also higher in patients with CAE and CAD compared with normal controls (0.26 ± 0.14 mg/L, 0.31 ± 0.27 mg/L vs 0.20 ± 0.06 mg/L, p = 0.04). The multivariate analysis indicated that RDW and CRP were the independent variables most strongly associated with the presence of isolated CAE and CAD. There was a positive correlation between levels of RDW and CRP in patients with isolated CAE (γ=0.532, p = 0.001).

Conclusions

Our data suggested that RDW may be a useful marker and independent predictor for the presence of isolated CAE.

【 授权许可】

   
2014 Li et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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