Cervical human papillomavirus prevalence and genotype distribution among hybrid capture 2 positive women 15 to 64 years of age in the Gurage zone, rural Ethiopia

Infectious Agents and Cancer

Ralph J Lellé⁴  Hartmut Goette²  Maurits NC de Koning³  Christof Prugger¹  Sami-Ramzi Leyh-Bannurah⁴ 

[1] INSERM, U970, Paris Cardiovascular Research Centre, University Paris Descartes, Sorbonne Paris Cité, Paris, France;Department of Molecular Diagnostics Europe, QIAGEN GmbH, Hilden, Germany;DDL Diagnostic Laboratory, Rijswijk, The Netherlands;Department of Gynecology and Obstetrics, University Hospital of Muenster, Muenster, Germany

关键词: Sub-Sahara Africa;    Risk factors;    Epidemiology;    HPV;    DNA probes;    Ethiopia;    Cervix uteri;    Papillomavirus infections;   

Others  :  1161153
DOI  :  10.1186/1750-9378-9-33

 received in 2014-05-28, accepted in 2014-09-16,  发布年份 2014

【 摘 要 】

Background

Human papillomavirus (HPV) infection is a prerequisite of cervical cancer, the leading cause of cancer mortality in Ethiopian women today. Data on Ethiopian cervical HPV prevalence and genotype distribution are rare, but essential as pre-vaccine baseline data to monitor changes after initiating HPV vaccination. The objectives of this study were to assess the cervical HPV prevalence, genotype distribution and associated correlates among female hospital outpatients in rural Ethiopia.

Methods

We examined a consecutive sample of 537 women 15–64 years of age in rural Ethiopia between November and December 2006. Screening for low risk (LR) and high-risk (HR) cervical HPV infection was performed and HR positive samples were genotyped with a GP5+/6 + − and SPF10-primer based system.

Results

The age-standardized prevalence of HPV, HPV HR and HPV LR infection was 17.3% (95% CI 14.1-20.5), 15.8% (95% CI 12.7-18.9) and 3.9% (95% CI 2.3-5.6), respectively. Among HC2 HPV HR positive infections (n = 86), the most common genotype was HPV 16 (24.4%), followed by 52 (11.6%), 56 (10.5%) and 31 (10.5%). Non-married relationship and widowhood, increasing number of lifetime sexual partners, human immunodeficiency virus infection and non-traditional housing type, but not age, were significantly associated with HR HPV infection.

Conclusions

These results on cervical HPV prevalence and genotype distribution may serve as baseline data in evaluating the impact of future HPV vaccination programmes in rural Ethiopia.

【 授权许可】

   
2014 Leyh-Bannurah et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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