Diffusion weighted imaging and blood oxygen level-dependent MR imaging of kidneys in patients with lupus nephritis

Journal of Translational Medicine

Nan Chen²  Fuhua Yan¹  Yan Liu²  Wen Zhang²  Hong Ren²  Qianying Zhang²  Xueqin Xu¹  Xiao Li² 

[1]Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

[2]Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

关键词: Pathological changes;    Renal function;    Functional MR imaging;    Lupus nephritis;   

Others  :  1147523
DOI  :  10.1186/s12967-014-0295-x

 received in 2014-08-04, accepted in 2014-10-10,  发布年份 2014

【 摘 要 】

Background

Lupus nephritis (LN) is one of most common secondary glomerulonephritis. There is no ideal method to simultaneously assess renal structure and function in patients with LN. The aim of this study is to investigate the utility of diffusion weighted imaging (DWI) and blood oxygen level-dependent (BOLD) MR imaging in the assessment of renal involvement and pathological changes in patients with LN.

Methods

Sixty-five patients with LN and 16 healthy volunteers underwent coronal echo-planar DWI and BOLD MR imaging of the kidneys. The apparent diffusion coefficient (ADC) and R2* values of the kidneys were calculated with b values of 0 and 500 s/mm². The relationship between the renal injury variables and the ADCs or R2* values were evaluated. And 16 of 65 patients with LN underwent a repeated evaluation after the induction treatment for 9 to 12 months.

Results

The mean ADC values of kidneys in patients with LN were 2.40?±?0.25 × 10^?3 mm²/ s, the mean R2* values of the renal cortex and medulla were 11.03?±?1.60/sec and 14.05?±?3.38/sec respectively, which were all significantly lower than that in volunteers. In patients with LN, the mean ADC values were correlated with eGFR (r?=?0.510, p?

Conclusions

DWI and BOLD MR imaging of kidneys may be used to noninvasively monitor the disease activity and evaluate therapeutic efficacy in lupus nephritis.

【 授权许可】

   
2014 Li et al.; licensee BioMed Central Ltd.

【 图 表 】

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