Tumorigenesis role and clinical significance of DJ-1, a negative regulator of PTEN, in supraglottic squamous cell carcinoma

Journal of Experimental & Clinical Cancer Research

Wei-Ping Wen¹  Yi-Hui Wen¹  Wei-Jian Hou¹  Hui-Wen Zhuang¹  Wen-Bin Lei¹  Zhang-Feng Wang¹  Xiao-Lin Zhu¹ 

[1] Otorhinolaryngology Institute, Sun Yat-Sen University, 2nd Zhongshan Road 58#, Guangzhou, 510080, Guangdong, P.R. China

关键词: Overall survival;    Supraglottic squamous cell carcinoma;    Tumorigenesis;    PTEN;    DJ-1;   

Others  :  825649
DOI  :  10.1186/1756-9966-31-94

 received in 2012-10-30, accepted in 2012-11-10,  发布年份 2012

【 摘 要 】

Background

DJ-1 can induce the tumor cell proliferation and invasion via down-regulating PTEN in many malignant tumors, and correlated to prognostic significance. However, the tumorigenesis role and clinical significance of DJ-1 in supraglottic squamous cell carcinoma (SSCC) is unclear. We aimed to evaluate the DJ-1 the relationship between DJ-1 and clinicopathological data including patient survival.

Methods

The expression of DJ-1 and PTEN in SSCCs (52) and adjacent non-cancerous tissues (42) was assessed by immunohistochemistry (IHC), and the relationship between DJ-1 and clinicopathological data was analyzed.

Results

DJ-1 was detected mainly in SSCCs (88.5%) and less frequently in adjacent non-cancerous tissues (21.0%). PTEN expression was detected in 46.2% of SSCCs and in 90.5% of adjacent non-cancerous tissues. DJ-1 expression was linked to nodal status (P = 0.009), a highly significant association of DJ-1 expression with shortened patient overall survival (5-year survival rate 88.0% versus 53.9%; P = 0.007; log rank test) was demonstrated.

Conclusions

Our data suggested that DJ-1 over-expression was linked to nodal status, and might be an independent prognostic marker for patients with SSCC.

【 授权许可】

   
2012 Zhu et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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