The Broad Street pump revisited: dairy farms and an ongoing outbreak of inflammatory bowel disease in Forest, Virginia

Gut Pathogens

Saleh A Naser²  Stephen M Borowitz³  Ellen S Pierce¹ 

[1] 13212 East Blossey Avenue, Spokane Valley, Washington, 99216 USA;Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, BMS Building, Room 221, University of Central Florida College of Medicine, 4000 Central Florida Boulevard, Orlando, Florida, 32816 USA;Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Virginia Children's Hospital, Box 800386 HSC, Charlottesville, Virginia 22908 USA

关键词: fecal-oral waterborne transmission;    aerosolization;    outbreak;    cluster;    paratuberculosis;    inflammatory bowel disease;   

Others  :  833636
DOI  :  10.1186/1757-4749-3-20

 received in 2011-12-07, accepted in 2011-12-23,  发布年份 2011

【 摘 要 】

We report an ongoing outbreak of ulcerative colitis and Crohn's disease in Forest, Virginia involving 15 unrelated children and teenagers who resided in close proximity to dairy farms. Some of our cases demonstrated serologic evidence of Mycobacterium avium subspecies paratuberculosis infection, suggesting its potential role as an etiologic agent.

【 授权许可】

   
2011 Pierce et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]Mapping the 1854 Broad Street Pump Outbreak [http://www.ph.ucla.edu/epi/snow/mapsbroadstreet.html] webcite
• [2]Uzoigwe JC, Khaitsa ML, Gibbs PS: Epidemiological evidence for Mycobacterium avium subspecies paratuberculosis as a cause of Crohn's disease. Epidemiol Infect 2007, 135:1057-1068.
• [3]Van Kruiningen HJ, Colombel JF, Cartun RW, Whitlock RH, Koopmans M, Kangro HO, Hoogkamp-Korstanje JA, Lecomte-Houcke M, Devred M, Paris JC, Cortot A: An in-depth study of Crohn's disease in two French families. Gastroenterology 1993, 104:351-360.
• [4]Van Kruiningen HJ, Joossens M, Vermeire S, Joossens S, Debeugny S, Gower-Rousseau C, Cortot A, Colombel JF, Rutgeerts P, Vlietinck R: Environmental factors in familial Crohn's disease in Belgium. Inflammatory bowel diseases 2005, 11:360-365.
• [5]Van Kruiningen HJ, Joossens M, Colombel JF: Cluster of Crohn's disease in Herny, France, including 2 cases from a common residence. Inflammatory bowel diseases 2007, 13:1454-1455.
• [6]Pickup RW, Rhodes G, Arnott S, Sidi-Boumedine K, Bull TJ, Weightman A, Hurley M, Hermon-Taylor J: Mycobacterium avium subsp. paratuberculosis in the catchment area and water of the River Taff in South Wales, United Kingdom, and its potential relationship to clustering of Crohn's disease cases in the city of Cardiff. Applied and environmental microbiology 2005, 71:2130-2139.
• [7]Van Kruiningen HJ, Freda BJ: A clustering of Crohn's disease in Mankato, Minnesota. Inflamm Bowel Dis 2001, 7:27-33.
• [8]Hermon-Taylor J, Bull TJ, Sheridan JM, Cheng J, Stellakis ML, Sumar N: Causation of Crohn's disease by Mycobacterium avium subspecies paratuberculosis. Can J Gastroenterol 2000, 14:521-539.
• [9]Pierce ES: Ulcerative colitis and Crohn's disease: is Mycobacterium avium subspecies paratuberculosis the common villain? Gut pathogens 2010, 2:21.
• [10]Jones PH, Farver TB, Beaman B, Cetinkaya B, Morgan KL: Crohn's disease in people exposed to clinical cases of bovine paratuberculosis. Epidemiol Infect 2006, 134:49-56.
• [11]Naser SA, Hulten K, Shafran I, Graham DY, El-Zaatari FA: Specific seroreactivity of Crohn's disease patients against p35 and p36 antigens of M. avium subsp. paratuberculosis. Vet Microbiol 2000, 77:497-504.
• [12]What is an outbreak? [http://www.cdc.gov/excite/classroom/outbreak/objectives.htm#what] webcite
• [13]Kugathasan S, Judd RH, Hoffmann RG, Heikenen J, Telega G, Khan F, Weisdorf-Schindele S, San Pablo W, Perrault J, Park R, Yaffe M, Brown C, Rivera-Bennett MT, Halabi I, Martinez A, Blank E, Werlin SL, Rudolph CD, Binion DG, Alliance WPIBD: Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a statewide population-based study. J Pediatr 2003, 143:525-531.
• [14]McKenna SL, Keefe GP, Tiwari A, VanLeeuwen J, Barkema HW: Johne's disease in Canada part II: disease impacts, risk factors, and control programs for dairy producers. Can Vet J 2006, 47:1089-1099.
• [15]Beumer A, King D, Donohue M, Mistry J, Covert T, Pfaller S: Detection of Mycobacterium avium subsp. paratuberculosis in drinking water and biofilms by quantitative PCR. Applied and environmental microbiology 2010, 76:7367-7370.
• [16]Falkinham JO: Surrounded by mycobacteria: nontuberculous mycobacteria in the human environment. J Appl Microbiol 2009, 107:356-367.
• [17]Lombard JE, Wagner BA, Smith RL, McCluskey BJ, Harris BN, Payeur JB, Garry FB, Salman MD: Evaluation of environmental sampling and culture to determine Mycobacterium avium subspecies paratuberculosis distribution and herd infection status on US dairy operations. J Dairy Sci 2006, 89:4163-4171.
• [18]Blanchard DC, Syzdek LD: Water-to-Air Transfer and Enrichment of Bacteria in Drops from Bursting Bubbles. Applied and environmental microbiology 1982, 43:1001-1005.
• [19]Primm TP, Lucero CA, Falkinham JO: Health impacts of environmental mycobacteria. Clinical microbiology reviews 2004, 17:98-106.
• [20]Libert C, Dejager L, Pinheiro I: The × chromosome in immune functions: when a chromosome makes the difference. Nat Rev Immunol 2010, 10:594-604.
• [21]Ferwerda G, Kullberg BJ, de Jong DJ, Girardin SE, Langenberg DM, van Crevel R, Ottenhoff TH, Van der Meer JW, Netea MG: Mycobacterium paratuberculosis is recognized by Toll-like receptors and NOD2. J Leukoc Biol 2007, 82:1011-1018.
• [22]Coulombe F, Divangahi M, Veyrier F, de Leseleuc L, Gleason JL, Yang Y, Kelliher MA, Pandey AK, Sassetti CM, Reed MB, Behr MA: Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide. J Exp Med 2009, 206:1709-1716.
• [23]Pinedo PJ, Buergelt CD, Donovan GA, Melendez P, Morel L, Wu R, Langaee TY, Rae DO: Association between CARD15/NOD2 gene polymorphisms and paratuberculosis infection in cattle. Vet Microbiol 2009, 134:346-352.
• [24]de Mesquita MB, Civitelli F, Levine A: Epidemiology, genes and inflammatory bowel diseases in childhood. Dig Liver Dis 2008, 40:3-11.
• [25]Divangahi M, Mostowy S, Coulombe F, Kozak R, Guillot L, Veyrier F, Kobayashi KS, Flavell RA, Gros P, Behr MA: NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity. J Immunol 2008, 181:7157-7165.