Serum vitamin D levels, diabetes and cardio-metabolic risk factors in Aboriginal and Torres Strait Islander Australians

Diabetology & Metabolic Syndrome

Kerin O’Dea¹  George Jerums⁵  Richard J MacIsaac⁸  Alan Cass⁷  Ashim Sinha⁴  Andrew Ellis⁵  Graham RD Jones⁶  Paul Lawton⁷  Kanakamani Jeyaraman¹  Zhong X Lu³  Jaquelyne T Hughes²  Louise J Maple-Brown² 

[1] University of South Australia, Adelaide, Australia;Division of Medicine, Royal Darwin Hospital, Darwin, Australia;Department of Medicine, Monash University, Melbourne, Australia;Cairns Base Hospital and Diabetes Centre, Cairns, Australia;Austin Health, Melbourne, Australia;University of NSW, Sydney, Australia;Menzies School of Health Research, Charles Darwin University, Darwin, Australia;University of Melbourne, Melbourne, Australia

关键词: Cardiovascular risk;    Aboriginal;    Type 2 diabetes;    25-hydroxy vitamin D;   

Others  :  1120463
DOI  :  10.1186/1758-5996-6-78

 received in 2014-03-21, accepted in 2014-06-26,  发布年份 2014

【 摘 要 】

Background

Low levels of serum 25–hydroxy vitamin D (25(OH)D), have been associated with development of type 2 diabetes and cardiovascular disease (CVD); however there are limited data on serum 25(OH)D in Indigenous Australians, a population at high risk for both diabetes and CVD. We aimed to assess levels of serum 25(OH)D in Aboriginal and Torres Strait Islander Australians and to explore relationships between 25(OH)D and cardio-metabolic risk factors and diabetes.

Methods

592 Aboriginal and/or Torres Strait Islander Australian participants of The eGFR (estimated glomerular filtration rate) Study, a cross-sectional analysis of a cohort study performed in 2007–2011, from urban and remote centres within communities, primary care and tertiary hospitals across Northern Territory, Far North Queensland and Western Australia. Assessment of serum 25(OH)D, cardio-metabolic risk factors (central obesity, diabetes, hypertension, history of cardiovascular disease, current smoker, low HDL-cholesterol), and diabetes (by history or HbA1c ≥6.5%) was performed. Associations were explored between 25(OH)D and outcome measures of diabetes and number of cardio-metabolic risk factors.

Results

The median (IQR) serum 25(OH)D was 60 (45–77) nmol/L, 31% had 25(OH)D <50 nmol/L. For participants with 25(OH)D < 50 vs ≥50 nmol/L, cardio-metabolic risk profile differed for: diabetes (54%, 36% p < 0.001), past history of cardiovascular disease (16%, 9%, p = 0.014), waist-hip ratio (0.98, 0.92, p < 0.001), urine albumin-creatinine ratio (2.7, 1.5 mg/mmol, p < 0.001). The OR (95% CI) for diabetes was 2.02 (1.03 – 3.95) for people in the lowest vs highest tertiles of 25(OH)D (<53 vs >72 nmol/L, respectively) after adjusting for known cardio-metabolic risk factors.

Conclusion

The percentage of 25(OH)D levels <50 nmol/L was high among Aboriginal and Torres Strait Islander Australians from Northern and Central Australia. Low 25(OH)D level was associated with adverse cardio-metabolic risk profile and was independently associated with diabetes. These findings require exploration in longitudinal studies.

【 授权许可】

   
2014 Maple-Brown et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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