Hepatopathy following consumption of a commercially available blue-green algae dietary supplement in a dog

BMC Veterinary Research

Birgit Puschner¹  Noemi Benitah²  Martha G. Cline²  Yanping Lin¹  Caroline E. Moore¹  Adrienne C. Bautista³ 

[1]Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USA

[2]Red Bank Veterinary Hospital, Tinton Falls, NJ, USA

[3]California Animal Health and Food Safety Laboratory System, Davis, CA, USA

关键词: Dietary supplement;    Toxicosis;    Hepatopathy;    Blue-green algae;    Microcystin;    Dog;   

Others  :  1219136
DOI  :  10.1186/s12917-015-0453-2

 received in 2015-02-06, accepted in 2015-06-09,  发布年份 2015

【 摘 要 】

Background

Dietary supplement use in both human and animals to augment overall health continues to increase and represents a potential health risk due to the lack of safety regulations imposed on the manufacturers. Because there are no requirements for demonstrating safety and efficacy prior to marketing, dietary supplements may contain potentially toxic contaminants such as hepatotoxic microcystins produced by several species of blue-green algae.

Case presentation

An 11-year-old female spayed 8.95 kg Pug dog was initially presented for poor appetite, lethargy polyuria, polydipsia, and an inability to get comfortable. Markedly increased liver enzyme activities were detected with no corresponding abnormalities evident on abdominal ultrasound. A few days later the liver enzyme activities were persistently increased and the dog was coagulopathic indicating substantial liver dysfunction. The dog was hospitalized for further care consisting of oral S-adenosylmethionine, silybin, vitamin K, and ursodeoxycholic acid, as well as intravenous ampicillin sodium/sulbactam sodium, dolasetron, N-acetylcysteine, metoclopramide, and intravenous fluids. Improvement of the hepatopathy and the dog’s clinical status was noted over the next three days. Assessment of the dog’s diet revealed the use of a commercially available blue-green algae dietary supplement for three-and-a-half weeks prior to hospitalization. The supplement was submitted for toxicology testing and revealed the presence of hepatotoxic microcystins (MCs), MC-LR and MC-LA. Use of the supplement was discontinued and follow-up evaluation over the next few weeks revealed a complete resolution of the hepatopathy.

Conclusions

To the authors’ knowledge, this is the first case report of microcystin intoxication in a dog after using a commercially available blue-green algae dietary supplement. Veterinarians should recognize the potential harm that these supplements may cause and know that with intervention, recovery is possible. In addition, more prudent oversight of dietary supplement use is recommended for our companion animals to prevent adverse events/intoxications.

【 授权许可】

   
2015 Bautista et al.

【 图 表 】

Fig. 1.

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